Jimenez-Vasquez Victor, Vargas-Herrera Natalia, Bárcena-Flores Luis, Hurtado Verónica, Padilla-Rojas Carlos, Araujo-Castillo Roger V
Centro Nacional de Salud Pública, Instituto Nacional de Salud, Capac Yupanqui 1400-Jesus Maria, Lima, Peru.
Genomics Inform. 2024 May 31;22(1):5. doi: 10.1186/s44342-024-00006-3.
During the third year of the pandemic in Peru, the persistent transmission of SARS-CoV-2 led to the appearance of more transmissible and immune-evasive Omicron sublineages; in that context, the National Genomic Surveillance of SARS-CoV-2 performed by the Peruvian National Institute of Health detected spike mutations in the circulating Omicron BA.5.1.25 sublineage which was later designated as DJ.1 and increased during the fourth COVID-19 wave, this eventually branched into new sublineages. The introduction, emergence, and timing of the most recent common ancestor (tMRCA) of BA.5.1.25 and its descendants (DJ.1, DJ.1.1, DJ.1.2, and DJ.1.3) were investigated in this paper as well as the time lags between their emergence and identification by the Peruvian National Institute of Health. Our findings show that ongoing genomic surveillance of SARS-CoV-2 is critical for understanding its phylogenetic evolution and the emergence of novel variations.
在秘鲁疫情的第三年，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的持续传播导致了更具传播性和免疫逃逸能力的奥密克戎亚谱系出现；在此背景下，秘鲁国家卫生研究院开展的SARS-CoV-2国家基因组监测在流行的奥密克戎BA.5.1.25亚谱系中检测到刺突蛋白突变，该亚谱系后来被命名为DJ.1，并在第四波新冠疫情期间增多，最终衍生出了新的亚谱系。本文研究了BA.5.1.25及其后代（DJ.1、DJ.1.1、DJ.1.2和DJ.1.3）最近共同祖先（tMRCA）的引入、出现时间及其后代的出现时间，以及它们出现与被秘鲁国家卫生研究院识别之间的时间间隔。我们的研究结果表明，持续开展SARS-CoV-2基因组监测对于了解其系统发育进化和新变异的出现至关重要。
