Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea.
ACS Appl Mater Interfaces. 2024 Jul 3;16(26):32945-32956. doi: 10.1021/acsami.4c01078. Epub 2024 Jun 24.
Photothermal therapy (PTT) is a promising cancer therapeutic approach due to its spatial selectivity and high potency. Indocyanine green (ICG) has been considered a biocompatible PTT agent. However, ICG has several challenges to hinder its clinical use including rapid blood clearance and instability to heat, light, and solvent, leading to a loss of photoactivation property and PTT efficacy. Herein, we leveraged stabilizing components, methyl-β-cyclodextrin and liposomes, in one nanoplatform (ICD lipo) to enhance ICG stability and the photothermal therapeutic effect against cancer. Compared to ICG, ICD lipo displayed a 4.8-fold reduction in degradation in PBS solvent after 30 days and a 3.4-fold reduction in photobleaching after near-infrared laser irradiation. Moreover, in tumor-bearing mice, ICD lipo presented a 2.7-fold increase in tumor targetability and inhibited tumor growth 9.6 times more effectively than did ICG without any serious toxicity. We believe that ICD lipo could be a potential PTT agent for cancer therapeutics.
光热疗法（PTT）由于其空间选择性和高效性，是一种很有前途的癌症治疗方法。吲哚菁绿（ICG）已被认为是一种生物相容性的 PTT 试剂。然而，ICG 存在一些挑战，包括快速血液清除和对热、光和溶剂的不稳定性，这导致其光激活性能和 PTT 疗效丧失。在这里，我们利用稳定化成分甲基-β-环糊精和脂质体在一个纳米平台（ICD lipo）中，以提高 ICG 的稳定性和抗癌的光热治疗效果。与 ICG 相比，ICD lipo 在 PBS 溶剂中 30 天后的降解减少了 4.8 倍，近红外激光照射后的光漂白减少了 3.4 倍。此外，在荷瘤小鼠中，ICD lipo 对肿瘤的靶向性增加了 2.7 倍，抑制肿瘤生长的效果比 ICG 高 9.6 倍，而没有任何严重的毒性。我们相信，ICD lipo 可能成为癌症治疗的一种有潜力的 PTT 试剂。
