Department of Thoracic Surgery, The Public Health Clinical Center of Chengdu, Chengdu, P.R. China.
PLoS One. 2024 Jun 24;19(6):e0305670. doi: 10.1371/journal.pone.0305670. eCollection 2024.
To compare the risk of developing subsequent primary lung cancer among cervical cancer patients and the general population.
Several databases were searched from inception to April 25, 2023. The standard incidence ratios (SIRs) with 95% confidence intervals (CIs) were combined to identify the risk for second primary lung cancer after cervical carcinoma. Subgroup analyses based on the follow-up period, age, degree of malignancy and source of SIR were conducted. All the statistical analyses were performed with STATA 15.0 software.
A total of 22 retrospective studies involving 864,627 participants were included. The pooled results demonstrated that cervical cancer patients had a significantly greater risk for lung cancer than did the general population (SIR = 2.63, 95% CI: 2.37-2.91, P<0.001). Furthermore, subgroup analyses stratified by follow-up period (<5 years and ≥5 years), age (≤50 years and <50 years), and degree of malignancy (invasive and in situ) also revealed an increased risk of developing lung cancer among cervical carcinoma patients.
Cervical cancer patients are more likely to develop subsequent primary lung cancer than the general population, regardless of age, follow-up time or degree of malignancy. However, more high-quality prospective studies are still needed to verify our findings.
比较宫颈癌患者与普通人群发生继发原发性肺癌的风险。
从建库至 2023 年 4 月 25 日，检索了多个数据库。采用合并标准发病率比（SIR）及其 95%置信区间（CI）来确定宫颈癌后发生第二原发性肺癌的风险。根据随访时间、年龄、恶性程度和 SIR 来源进行亚组分析。所有统计分析均采用 STATA 15.0 软件进行。
共纳入 22 项回顾性研究，涉及 864627 名参与者。汇总结果表明，宫颈癌患者发生肺癌的风险显著高于普通人群（SIR=2.63，95%CI：2.37-2.91，P<0.001）。此外，按随访时间（<5 年和≥5 年）、年龄（≤50 岁和<50 岁）和恶性程度（浸润性和原位）进行的亚组分析也显示，宫颈癌患者发生肺癌的风险增加。
无论年龄、随访时间或恶性程度如何，宫颈癌患者发生继发原发性肺癌的可能性均高于普通人群。然而，仍需要更多高质量的前瞻性研究来验证我们的发现。
