Hogea Bogdan, Suba Madalina-Ianca, Abu-Awwad Simona-Alina, Cuntan Paul, Popa Mihai-Valetin, Braescu Ruben David, Abu-Awwad Ahmed
Department XV-Discipline of Orthopedics-Traumatology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
"Pius Brinzeu" Emergency Clinical County Hospital, Bld Liviu Rebreanu, No. 156, 300723 Timisoara, Romania.
Life (Basel). 2024 May 23;14(6):671. doi: 10.3390/life14060671.
This study investigates the correlation between COVID-19 and avascular necrosis of the femoral head, considering the potential contribution of medication-induced effects. This research spans the period from August 2022 to January 2024 and includes 32 patients diagnosed with avascular necrosis. While steroid usage, particularly in high doses, is known to predispose individuals to this condition, this study aims to discern if COVID-19 itself plays a role beyond the influence of medication. Notably, COVID-19 is associated with disturbances in the coagulation system, potentially leading to thromboembolic complications. Of the patients, six did not have COVID-19, while seven had the virus but did not receive steroid treatment. However, 19 patients with COVID-19 exhibited severe pulmonary involvement and were administered both high-dose steroids and antiviral medication. Among the observed patients, 14 were female and 18 were male. Notably, three patients presented bilateral necrosis, all of whom had COVID-19 and significant pulmonary involvement. Diagnostic assessments included frontal and profile X-rays, as well as MRI scans for all patients.
本研究探讨了新冠病毒（COVID-19）与股骨头缺血性坏死之间的相关性，并考虑了药物诱导效应的潜在影响。本研究涵盖了2022年8月至2024年1月期间，纳入了32例被诊断为缺血性坏死的患者。虽然已知使用类固醇，尤其是高剂量使用，会使个体易患这种疾病，但本研究旨在确定COVID-19本身是否在药物影响之外发挥作用。值得注意的是，COVID-19与凝血系统紊乱有关，可能导致血栓栓塞并发症。在这些患者中，6例没有感染COVID-19，7例感染了病毒但未接受类固醇治疗。然而，19例感染COVID-19的患者出现了严重的肺部受累，并接受了高剂量类固醇和抗病毒药物治疗。在观察到的患者中，14例为女性，18例为男性。值得注意的是，3例患者出现双侧坏死，所有这些患者都感染了COVID-19且有严重的肺部受累。诊断评估包括对所有患者进行正位和侧位X线检查以及磁共振成像（MRI）扫描。
