Evermann J F, Liggitt H D, Parish S M, Ward A C, LeaMaster B R
Am J Vet Res. 1985 Apr;46(4):947-51.
A virus isolated from a yearling cross-bred ewe was identified as respiratory syncytial virus (RSV) by indirect immunofluorescence and by virus neutralization with bovine RSV antisera. The virus caused a mild conjunctivitis in 3-month-old lambs when inoculated alone. Although clinical signs of pneumonia were not observed, there was gross and microscopic evidence of pulmonary inflammation in the lungs of lambs inoculated with either the sheep RSV isolate alone or in conjunction with Pasteurella haemolytica. Lung lesions in the dual infection were more severe, with approximately 10% of the total lung mass affected. Lavage fluids from lambs inoculated with virus and bacteria contained approximately 3 times more inflammatory cells than from control lambs or lambs inoculated with virus only. The sheep RSV isolate was classified as a mild respiratory pathogen in lambs of this age. Speculations on the potential importance of this virus in interspecies transmission to cattle and goats were discussed.
通过间接免疫荧光法以及用牛呼吸道合胞病毒抗血清进行病毒中和试验，从一头一岁杂交母羊身上分离出的病毒被鉴定为呼吸道合胞病毒（RSV）。单独接种该病毒时，它会在3月龄羔羊中引发轻度结膜炎。尽管未观察到肺炎的临床症状，但在单独接种绵羊RSV分离株或与溶血巴斯德菌联合接种的羔羊肺部，有肉眼可见和显微镜下的肺部炎症证据。双重感染时的肺部病变更严重，约占肺总量的10%。接种病毒和细菌的羔羊的灌洗液中炎症细胞数量比对照羔羊或仅接种病毒的羔羊多约3倍。该绵羊RSV分离株在这个年龄段的羔羊中被归类为轻度呼吸道病原体。文中还讨论了这种病毒在跨物种传播给牛和山羊方面潜在重要性的推测。
