Grundmann R, Heistermann S
Arch Surg. 1985 Aug;120(8):911-5. doi: 10.1001/archsurg.1985.01390320035006.
In a prospectively randomized trial of 220 patients, 106 were given albumin when their colloid osmotic pressure (COP) fell below 24 cm H2O and 114 were given albumin when their COP fell below 29 cm H2O. There was no difference in the postoperative course between the two groups; however, by using the lower COP limit the postoperative albumin consumption in the intensive care unit was reduced significantly and thus the costs of treatment were lowered. In the case of extremely low COP, the prognosis of the disease worsened, indicating that the COP is of prognostic value. The albumin supply, however, did not influence the final outcome of the patients under these circumstances because it treated only a characteristic symptom and not the cause of the disease.
在一项针对220名患者的前瞻性随机试验中，106名患者在其胶体渗透压（COP）降至24厘米水柱以下时接受白蛋白治疗，114名患者在其COP降至29厘米水柱以下时接受白蛋白治疗。两组患者的术后病程没有差异；然而，通过采用较低的COP下限，重症监护病房的术后白蛋白消耗量显著降低，从而降低了治疗成本。在COP极低的情况下，疾病预后恶化，这表明COP具有预后价值。然而，在这些情况下，白蛋白供应并未影响患者的最终结局，因为它仅治疗了一种特征性症状，而非疾病的病因。
