N6-甲基腺嘌呤修饰在胚胎干细胞维持与分化中的调控作用
The regulatory role of mA modification in the maintenance and differentiation of embryonic stem cells.
作者信息
Zhang Jin, Tong Lingling, Liu Yuchen, Li Xiang, Wang Jiayi, Lin Ruoxin, Zhou Ziyu, Chen Yunbing, Chen Yanxi, Liu Yirong, Chen Di
机构信息
Center for Reproductive Medicine of the Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
出版信息
Genes Dis. 2023 Dec 19;11(5):101199. doi: 10.1016/j.gendis.2023.101199. eCollection 2024 Sep.
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, -methyladenosine (mA) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. mA modification is regulated by mA writers, erasers, and readers. Emerging evidence suggests that mA modification plays essential roles in modulating the cell-fate transition of embryonic stem cells. Mechanistic investigation of embryonic stem cell maintenance and differentiation is critical for understanding early embryonic development, which is also the premise for the application of embryonic stem cells in regenerative medicine. This review highlights the current knowledge of mA modification and its essential regulatory contribution to the cell fate transition of mouse and human embryonic stem cells.
作为真核生物信使核糖核酸（mRNA）中最普遍且可逆的内部表观遗传修饰，N6-甲基腺苷（m6A）在转录后调控参与多种生物学过程的mRNA的加工和代谢。m6A修饰由m6A写入器、擦除器和读取器调控。新出现的证据表明，m6A修饰在调节胚胎干细胞的细胞命运转变中起关键作用。对胚胎干细胞维持和分化的机制研究对于理解早期胚胎发育至关重要，这也是胚胎干细胞在再生医学中应用的前提。本综述重点介绍了目前关于m6A修饰及其对小鼠和人类胚胎干细胞细胞命运转变的重要调控作用的知识。
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