特立尼达和多巴哥的 EQ-5D-5L 估值研究。

The EQ-5D-5L valuation study for Trinidad and Tobago.

机构信息

Department of Economics, The University of the West Indies, St Augustine Campus, St Augustine, Trinidad and Tobago.

HEU, Centre for Health Economics, The University of the West Indies, St Augustine Campus, St Augustine, Trinidad and Tobago.

出版信息

Health Qual Life Outcomes. 2024 Jul 2;22(1):51. doi: 10.1186/s12955-024-02266-7.

DOI:10.1186/s12955-024-02266-7

PMID:38956543

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11218064/

Abstract

PURPOSE

The 2016 EQ-5D-3L value set for Trinidad and Tobago (T&T) allows for the calculation of EQ-5D-5L values via the crosswalk algorithm. The 2016 value set was based on methods predating the EQ-VT protocol, now considered the gold standard for developing EQ-5D value sets. Furthermore, direct elicitation of EQ-5D-5L is preferred over crosswalked values. This study aimed to produce an EQ-5D-5L value set for T&T.

METHODS

A representative sample (age, sex, geography) of adults each completed 10 composite Time Trade-Off (cTTO) tasks and 12 Discrete Choice Experiment (DCE) tasks in face-to-face interviews. The cTTO data were analyzed using a Tobit model that corrects for heteroskedasticity. DCE data were analyzed using a mixed logit model. The cTTO and DCE data were combined in hybrid models.

RESULTS

One thousand and seventy-nine adults completed the valuation interviews. Among the modelling approaches that were explored, the hybrid heteroskedastic Tobit model produced all internally consistent, statistically significant coefficients, and performed best in terms of out-of-sample predictivity for single states. Compared to the existing EQ-5D-5L crosswalk set, the new value set had a higher number of negative values (236 or 7.6% versus 21 or 0.7%). The mean absolute difference was 0.157 and the correlation coefficient between the two sets was 0.879.

CONCLUSION

This study provides a value set for the EQ-5D-5L for T&T using the EQ-VT protocol. We recommend this value set for QALY computations relating to T&T.

摘要

目的

特立尼达和多巴哥（T&T）的 2016 年 EQ-5D-3L 值集允许通过交叉算法计算 EQ-5D-5L 值。该 2016 年值集是基于早于 EQ-VT 协议的方法制定的，EQ-VT 协议现在被认为是制定 EQ-5D 值集的金标准。此外，直接 elicitation 的 EQ-5D-5L 比交叉值更受欢迎。本研究旨在为 T&T 制定 EQ-5D-5L 值集。

方法

代表性样本（年龄、性别、地理位置）的成年人每人在面对面访谈中完成了 10 项复合时间贸易（cTTO）任务和 12 项离散选择实验（DCE）任务。使用 Tobit 模型分析 cTTO 数据，该模型纠正了异方差。使用混合对数模型分析 DCE 数据。将 cTTO 和 DCE 数据合并到混合模型中。

结果

1079 名成年人完成了估值访谈。在所探索的建模方法中，混合异方差 Tobit 模型产生了所有内部一致、统计学上显著的系数，并且在单状态外推预测方面表现最好。与现有的 EQ-5D-5L 交叉集相比，新值集的负值数量更多（236 或 7.6%，而 21 或 0.7%）。平均绝对差为 0.157，两个集之间的相关系数为 0.879。