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弥合微观差异:微结晶和体内结晶学的全面概述。

Bridging the microscopic divide: a comprehensive overview of micro-crystallization and in vivo crystallography.

机构信息

NUSR, Nagoya University, Nagoya, Japan.

Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

出版信息

IUCrJ. 2024 Jul 1;11(Pt 4):476-485. doi: 10.1107/S205225252400513X.

DOI:10.1107/S205225252400513X
PMID:38958014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11220871/
Abstract

A series of events underscoring the significant advancements in micro-crystallization and in vivo crystallography were held during the 26th IUCr Congress in Melbourne, positioning microcrystallography as a pivotal field within structural biology. Through collaborative discussions and the sharing of innovative methodologies, these sessions outlined frontier approaches in macromolecular crystallography. This review provides an overview of this rapidly moving field in light of the rich dialogues and forward-thinking proposals explored during the congress workshop and microsymposium. These advances in microcrystallography shed light on the potential to reshape current research paradigms and enhance our comprehension of biological mechanisms at the molecular scale.

摘要

一系列突显微量结晶学和活体结晶学重大进展的活动在墨尔本举行的第 26 届国际晶体学联合会大会期间举行,使微量结晶学成为结构生物学中的一个关键领域。通过协作讨论和创新方法的分享,这些会议概述了大分子晶体学的前沿方法。鉴于大会研讨会和小组讨论中探讨的丰富对话和前瞻性建议,本综述概述了这一快速发展领域。这些微量结晶学的进展为重塑当前研究范式并增强我们对分子水平生物机制的理解提供了潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/c9cd8026dff3/m-11-00476-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/fa1dabdc9c12/m-11-00476-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/8297bbfcbb8d/m-11-00476-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/c9cd8026dff3/m-11-00476-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/fa1dabdc9c12/m-11-00476-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/8297bbfcbb8d/m-11-00476-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee9/11220871/c9cd8026dff3/m-11-00476-fig3.jpg

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