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鼻咽癌：连接生前和死后发现以突出一例罕见的EB病毒和人乳头瘤病毒阴性病例

Nasopharyngeal Carcinoma: Connecting Antemortem and Postmortem Findings to Highlight a Rare Case of EBV and HPV Negativity.

作者信息

Auen Thomas, Talmon Geoffrey

机构信息

University of Nebraska Medical Center Department of Pathology, Microbiology, and Immunology 983135 Nebraska Medical Center Medical Science Building, 3rd Floor, Omaha, NE 68198, USA.

出版信息

Case Rep Pathol. 2024 Jun 10;2024:8881912. doi: 10.1155/2024/8881912. eCollection 2024.

DOI:10.1155/2024/8881912
PMID:38962102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11221976/
Abstract

Nasopharyngeal carcinoma is an endemic entity with a strong association with Epstein-Barr virus and a new recognition of human papilloma virus-mediated effects in nonendemic areas. Here, we discuss a nasopharyngeal carcinoma suspected as based on imaging results with metastasis to the lymph nodes, lung, spleen, bone, and liver. Gross and microscopic findings from the autopsy were clinicopathologically correlated with antemortem clinical studies and investigations. The authors report a case of EBV- and HPV-negative nonendemic, multisite metastatic nasopharyngeal carcinoma, shown to be nonkeratinizing undifferentiated subtype.

摘要

鼻咽癌是一种地方病实体，与爱泼斯坦-巴尔病毒密切相关，并且在非流行地区对人乳头瘤病毒介导的效应有了新的认识。在此，我们讨论一例根据影像学结果怀疑为鼻咽癌且伴有淋巴结、肺、脾、骨和肝转移的病例。尸检的大体和显微镜检查结果与生前临床研究及调查进行了临床病理相关性分析。作者报告了一例爱泼斯坦-巴尔病毒和人乳头瘤病毒均为阴性的非地方性、多部位转移的鼻咽癌病例，显示为非角化未分化亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/b067fcc230d0/CRIPA2024-8881912.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/9e30a81baaac/CRIPA2024-8881912.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/1ba58c4ad48f/CRIPA2024-8881912.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/3e833e096db4/CRIPA2024-8881912.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/ac86c518326e/CRIPA2024-8881912.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/9f2ec21f6e43/CRIPA2024-8881912.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/b067fcc230d0/CRIPA2024-8881912.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/9e30a81baaac/CRIPA2024-8881912.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/1ba58c4ad48f/CRIPA2024-8881912.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/3e833e096db4/CRIPA2024-8881912.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/ac86c518326e/CRIPA2024-8881912.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/9f2ec21f6e43/CRIPA2024-8881912.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d4/11221976/b067fcc230d0/CRIPA2024-8881912.006.jpg

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本文引用的文献

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SMARCB1-Deficient Sinonasal Carcinoma: Case Report and Review of the Literature.SMARCB1 缺陷性鼻腔鼻窦癌：病例报告及文献复习。
Am J Case Rep. 2023 May 18;24:e939244. doi: 10.12659/AJCR.939244.
3
A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma.一例存在组织学诊断难题的舌淋巴上皮癌病例报告。
Diagnostics (Basel). 2021 Jun 4;11(6):1039. doi: 10.3390/diagnostics11061039.
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Prevalence of Nasopharyngeal Carcinoma in Patients with Dermatomyositis: A Systematic Review and Meta-Analysis.皮肌炎患者鼻咽癌的患病率：一项系统评价和荟萃分析
Cancers (Basel). 2021 Apr 14;13(8):1886. doi: 10.3390/cancers13081886.
5
Clinical and survival analysis of nasopharyngeal carcinoma with consistently negative Epstein-Barr virus DNA.持续 EBV-DNA 阴性鼻咽癌的临床和生存分析。
Head Neck. 2021 May;43(5):1465-1475. doi: 10.1002/hed.26608. Epub 2021 Jan 9.
6
A Rare Case of Sinonasal Lymphoepithelial Carcinoma Presented With Clinically Stage IV Disease.鼻腔鼻窦淋巴上皮癌 1 例报道，临床分期为 IV 期。
Ear Nose Throat J. 2022 Jul;101(6):386-391. doi: 10.1177/0145561320955125. Epub 2020 Sep 30.
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Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: A nationwide study in Finland.爱泼斯坦-巴尔病毒和人乳头瘤病毒作为鼻咽癌的有利预后因素：芬兰的一项全国性研究。
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