Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Am J Trop Med Hyg. 2024 Jul 3;111(1):132-135. doi: 10.4269/ajtmh.23-0701.
Blood stream infection with Microbacterium species in humans is rare and frequently linked to the presence of immunosuppressed conditions such as patients on chemotherapy or corticosteroids. Presence of indwelling catheters is also a potential risk factor for M. aurum infection. No case report has been documented in the literature regarding the pathogenic potential of M. aurum in causing bacteremia. This is the first case series reporting bacteremia by M. aurum describing the risk factors and sensitivity pattern of this pathogen. In this case series, we have described bacteremia caused by M. aurum. The risk factors and sensitivity pattern of this pathogen have also been evaluated. Here, we describe the clinical course and presentation of three patients whose blood culture showed growth of M. aurum. Indwelling venous catheter for hemodialysis or for chemotherapy for the treatment of acute lymphoblastic leukemia was found to be a risk factor in two patients. Rheumatoid arthritis was the underlying condition in the second patient and was started on immunosuppressants. Blood samples were collected during the febrile period. The blood culture samples of all these patients had pure isolates of M. aurum, identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. All three patients were managed according to the sensitivity reports and were discharged in stable condition.
人类血流感染微杆菌属的情况较为罕见，且常与免疫抑制状态相关，例如接受化疗或皮质类固醇治疗的患者。留置导管也是金分枝杆菌感染的一个潜在危险因素。目前文献中尚无金分枝杆菌导致菌血症的致病性病例报告。本研究为首次报道金分枝杆菌导致菌血症的病例系列，旨在阐述该病原体的危险因素和药敏模式。在本病例系列中，我们描述了金分枝杆菌导致的菌血症，评估了该病原体的危险因素和药敏模式。本文描述了三例血培养出金分枝杆菌的患者的临床经过和表现。两例患者的危险因素为用于血液透析或急性淋巴细胞白血病治疗的化疗的留置静脉导管。第二位患者存在类风湿关节炎，开始使用免疫抑制剂。在发热期间采集血样。所有患者的血培养样本均通过基质辅助激光解吸电离飞行时间质谱鉴定为纯金分枝杆菌分离株。所有三位患者均根据药敏报告进行管理，病情稳定后出院。
