Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Department of Basic Medical Sciences, Faculty of Medicine, Galala University, New Galala City, Suez, 43511, Egypt.
Sci Rep. 2024 Jul 5;14(1):15538. doi: 10.1038/s41598-024-65235-6.
Drug delivery is the process or method of delivering a pharmacological product to have therapeutic effects on humans or animals. The use of nanoparticles to deliver medications to cells is driving the present surge in interest in improving human health. Green nanodrug delivery methods are based on chemical processes that are acceptable for the environment or that use natural biomaterials such as plant extracts and microorganisms. In this study, zinc oxide-superparamagnetic iron oxide-silver nanocomposite was synthesized via green synthesis method using Fusarium oxysporum fungi mycelia then loaded with sorafenib drug. The synthesized nanocomposites were characterized by UV-visibile spectroscopy, FTIR, TEM and SEM techniques. Sorafenib is a cancer treatment and is also known by its brand name, Nexavar. Sorafenib is the only systemic medication available in the world to treat hepatocellular carcinoma. Sorafenib, like many other chemotherapeutics, has side effects that restrict its effectiveness, including toxicity, nausea, mucositis, hypertension, alopecia, and hand-foot skin reaction. In our study, 40 male albino rats were given a single dose of diethyl nitrosamine (DEN) 60 mg/kg b.wt., followed by carbon tetrachloride 2 ml/kg b.wt. twice a week for one month. The aim of our study is using the zinc oxide-superparamagnetic iron oxide-silver nanocomposite that was synthesized by Fusarium oxysporum fungi mycelia as nanocarrier for enhancement the sorafenib anticancer effect.
药物输送是将药物递送到人体或动物体内以产生治疗效果的过程或方法。利用纳米颗粒将药物递送到细胞中，这推动了目前提高人类健康的兴趣热潮。绿色纳米药物输送方法基于对环境可接受的化学过程，或使用天然生物材料，如植物提取物和微生物。在本研究中，通过使用尖孢镰刀菌真菌菌丝的绿色合成方法合成了氧化锌-超顺磁性氧化铁-银纳米复合材料，然后负载索拉非尼药物。通过紫外可见光谱、FTIR、TEM 和 SEM 技术对合成的纳米复合材料进行了表征。索拉非尼是一种癌症治疗药物，也以其商品名 Nexavar 而闻名。索拉非尼是世界上唯一可用于治疗肝细胞癌的系统药物。与许多其他化疗药物一样，索拉非尼也有副作用，限制了其疗效，包括毒性、恶心、粘膜炎、高血压、脱发和手足皮肤反应。在我们的研究中，给 40 只雄性白化大鼠单次给予二乙基亚硝胺 60mg/kg b.wt.，然后每周两次给予 2ml/kg b.wt.四氯化碳一个月。我们研究的目的是使用通过尖孢镰刀菌真菌菌丝合成的氧化锌-超顺磁性氧化铁-银纳米复合材料作为纳米载体来增强索拉非尼的抗癌效果。
