Yang Fuhong, Lv Jingqi, Ma Wen, Yang Yanling, Hu Xiaoming, Yang Zhen
Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Key Laboratory of Flexible Electronics, Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE), Fuzhou, 350117, China.
Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330013, China.
Small. 2024 Nov;20(44):e2402669. doi: 10.1002/smll.202402669. Epub 2024 Jul 6.
Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising therapy approach for deep-seated tumors. However, the general or only utilization of SDT shows low efficiency and unsatisfactory treatment outcomes due to the complicated tumor microenvironment (TME) and SDT process. To circumvent the issues, three feasible approaches for enhancing SDT-based therapeutic effects, including sonosensitizer optimization, strategies for conquering hypoxia TME, and combinational therapy are summarized, with a particular focus on the combination therapy of SDT with other therapy modalities, including chemodynamic therapy, photodynamic therapy, photothermal therapy, chemotherapy, starvation therapy, gas therapy, and immunotherapy. In the end, the current challenges in SDT-based therapy on tumors are discussed and feasible approaches for enhanced therapeutic effects are provided. It is envisioned that this review will provide new insight into the strategic design of high-efficiency sonosensitizer-derived nanotheranostics, thereby augmenting SDT and accelerating the potential clinical transformation.
声动力疗法（SDT）具有无创、穿透性强、成本低和可重复性等特点，是一种治疗深部肿瘤的有前景的治疗方法。然而，由于复杂的肿瘤微环境（TME）和声动力疗法过程，单纯或仅使用声动力疗法显示出效率低下和治疗效果不尽人意。为了规避这些问题，总结了三种增强基于声动力疗法治疗效果的可行方法，包括声敏剂优化、克服缺氧肿瘤微环境的策略和联合治疗，特别关注声动力疗法与其他治疗方式的联合治疗，包括化学动力疗法、光动力疗法、光热疗法、化疗、饥饿疗法、气体疗法和免疫疗法。最后，讨论了基于声动力疗法治疗肿瘤目前面临的挑战，并提供了增强治疗效果的可行方法。预计这篇综述将为高效声敏剂衍生的纳米诊疗策略设计提供新的见解，从而增强声动力疗法并加速潜在的临床转化。
