用于研究磷脂酸介导的信号转导的偶氮类似物的合成。

Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling.

机构信息

Texas A & M University School of Medicine, Houston, TX, USA.

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine at University of Miami, Miami, FL, USA.

出版信息

Methods Mol Biol. 2024;2816:139-144. doi: 10.1007/978-1-0716-3902-3_13.

DOI:10.1007/978-1-0716-3902-3_13

PMID:38977595

Abstract

Phosphatidic acid (PA) is a key signaling lipid that plays a crucial role in regulating various cellular processes. Studies have shown that azobenzene-containing PA analogues can be used as an all-chemical strategy for light-mediated control of PA signaling. These photoswitchable lipids offer a solution to the limitations of traditional bulk dosing methods by allowing for light- and shape-dependent interactions with protein effectors and lipid-metabolizing enzymes. This chapter describes how to synthesize AzoPA and dAzoPA.

摘要

磷脂酸（PA）是一种关键的信号脂质，在调节各种细胞过程中起着至关重要的作用。研究表明，含偶氮苯的 PA 类似物可用作一种全化学策略，用于通过光来控制 PA 信号。这些光致变色脂质通过与蛋白效应器和脂质代谢酶的光依赖性和形状依赖性相互作用，为传统的批量给药方法的局限性提供了解决方案。本章描述了如何合成 AzoPA 和 dAzoPA。