Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
BMC Biol. 2011 Dec 2;9:85. doi: 10.1186/1741-7007-9-85.
The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
脂质磷脂酸（PA）在所有生物体的细胞信号转导和代谢调节中都具有重要作用。新的证据表明，PA 还具有作为 pH 生物传感器的前所未有的作用，将 pH 的变化与细胞内信号通路相耦合。pH 感应是 PA 的磷酸单酯头基的特性。许多其他有效的信号脂质也含有磷酸单酯的头基，这意味着脂质的 pH 感应在生物学中可能很普遍。
