State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China.
The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, China.
Oxid Med Cell Longev. 2023 Apr 10;2023:8003821. doi: 10.1155/2023/8003821. eCollection 2023.
Diseases in the nervous system are common in the human body. People have to suffer a great burden due to huge economic costs and poor prognosis of the diseases. Many treatment modalities are now available that can make recovery better. Managing nutritional factors is also helpful for such diseases. The basic fibroblast growth factor (bFGF) is one of the major nutritional factors, which plays a crucial role in organogenesis and tissue homeostasis. It plays a role in cell proliferation, migration, and differentiation, thereby regulating angiogenesis and wound healing and repair of the muscle, bone, and nerve. The study on how to improve the stability of bFGF to increase the treatment effect for different diseases has garnered tremendous attention. Biomaterials are the popular methods to improve the stability of bFGF because they are safe for the living body as they are biocompatible. Biomaterials can be loaded with bFGF and delivered locally to achieve the goal of sustained bFGF release. In the present review, we report different types of biomaterials that are used for bFGF delivery for nerve repair and briefly report how the introduced bFGF can function in the nervous system. We aim to provide summative guidance for future studies about nerve injury using bFGF.
神经系统疾病在人体中很常见。由于疾病的巨大经济成本和预后不良，人们不得不承受巨大的负担。现在有许多治疗方法可以使康复效果更好。管理营养因素对这类疾病也有帮助。碱性成纤维细胞生长因子（bFGF）是主要的营养因子之一，在器官发生和组织稳态中起着至关重要的作用。它在细胞增殖、迁移和分化中发挥作用，从而调节血管生成和伤口愈合以及肌肉、骨骼和神经的修复。如何提高 bFGF 的稳定性以提高其对不同疾病的治疗效果的研究引起了极大的关注。生物材料是提高 bFGF 稳定性的常用方法，因为它们具有生物相容性，对活体安全。生物材料可以负载 bFGF 并局部递送，以实现持续释放 bFGF 的目标。在本综述中，我们报告了用于神经修复的 bFGF 递送的不同类型的生物材料，并简要报告了引入的 bFGF 如何在神经系统中发挥作用。我们旨在为使用 bFGF 治疗神经损伤的未来研究提供总结性指导。
