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[冷等离子体在伤口愈合中的应用]

[Cold plasma in wound healing].

作者信息

Werra Ursula Elisabeth Maria, Dorweiler Bernhard

机构信息

Klinik und Poliklinik für Gefäßchirurgie, Vaskuläre und endovaskuläre Chirurgie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

出版信息

Urologie. 2025 Jan;64(1):52-58. doi: 10.1007/s00120-024-02376-6. Epub 2024 Jul 10.

DOI:10.1007/s00120-024-02376-6
PMID:38985295
Abstract

Even today, not all wounds can be healed. Treatment, which often takes many years, is a burden for patients and is very cost-intensive. Therefore, additional procedures such as cold plasma are becoming increasingly popular. Active components of cold plasma include electromagnetic radiation and free radicals. The active principle is based on, among other things, damage to bacterial cells and positive interaction with epithelial and endothelial cells. Angiogenesis and cellular oxygen metabolism are stimulated. The evidence base is still limited and heterogeneous, as some results are contradictory and comparability is difficult. However, new, well-designed studies have confirmed previous findings. In order to create a solid database, further studies are needed.

摘要

即使在今天,并非所有伤口都能愈合。治疗往往需要数年时间,这对患者来说是一种负担,而且成本很高。因此,诸如冷等离子体等额外的治疗方法越来越受欢迎。冷等离子体的活性成分包括电磁辐射和自由基。其作用原理除其他外,基于对细菌细胞的损伤以及与上皮细胞和内皮细胞的积极相互作用。它能刺激血管生成和细胞氧代谢。证据基础仍然有限且参差不齐,因为一些结果相互矛盾,难以进行比较。然而,新的、设计良好的研究证实了先前的发现。为了建立一个坚实的数据库,还需要进一步的研究。

相似文献

1
[Cold plasma in wound healing].[冷等离子体在伤口愈合中的应用]
Urologie. 2025 Jan;64(1):52-58. doi: 10.1007/s00120-024-02376-6. Epub 2024 Jul 10.
2
Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers: A Randomized Clinical Trial.冷大气压等离子体疗法与标准治疗安慰剂对糖尿病足溃疡患者伤口愈合的影响:一项随机临床试验。
JAMA Netw Open. 2020 Jul 1;3(7):e2010411. doi: 10.1001/jamanetworkopen.2020.10411.
3
Cold Atmospheric Pressure Plasma: A Growing Paradigm in Diabetic Wound Healing-Mechanism and Clinical Significance.冷大气压等离子体:糖尿病创面愈合的新兴模式——机制与临床意义。
Int J Mol Sci. 2023 Nov 23;24(23):16657. doi: 10.3390/ijms242316657.
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Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode.冷等离体气体(CAP)会激活皮肤角质形成细胞、成纤维细胞和内皮细胞中的血管生成相关分子,并以自分泌和旁分泌的方式促进伤口血管生成。
J Dermatol Sci. 2018 Feb;89(2):181-190. doi: 10.1016/j.jdermsci.2017.11.008. Epub 2017 Nov 26.
5
Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing.冷等离体子体促进不同类型的表浅皮肤蚀伤创面愈合。
Int Wound J. 2019 Oct;16(5):1103-1111. doi: 10.1111/iwj.13161. Epub 2019 Jun 17.
6
Use of Cold Plasma in Wound Healing: A Case Report.冷等离子体在伤口愈合中的应用:一例报告。
Adv Skin Wound Care. 2022 Dec 1;35(12):1-3. doi: 10.1097/01.ASW.0000891084.22486.a7.
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Healing wounds with plasma-activated hydrogel therapy.采用等离子体活化水凝胶疗法治疗伤口。
Trends Biotechnol. 2025 Feb;43(2):278-289. doi: 10.1016/j.tibtech.2024.07.013. Epub 2024 Aug 28.
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[Cold atmospheric pressure plasma for the treatment of acute and chronic wounds].[冷大气压等离子体用于急慢性伤口的治疗]
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Biological solutions activated by cold plasma at atmospheric pressure: A new therapeutic approach for skin wound healing.大气压下冷等离子体激活的生物溶液:皮肤伤口愈合的一种新治疗方法。
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The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo.冷等离体等离子体作为一种新型疗法治疗糖尿病创面的体外和体内疗效及安全性。
Int Wound J. 2020 Jun;17(3):851-863. doi: 10.1111/iwj.13341. Epub 2020 Mar 13.

本文引用的文献

1
Cold atmospheric plasma applications in dermatology: A systematic review.低温常压等离子体在皮肤科的应用:系统综述。
J Biophotonics. 2021 Mar;14(3):e202000415. doi: 10.1002/jbio.202000415. Epub 2020 Dec 21.
2
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J Dtsch Dermatol Ges. 2020 Oct;18(10):1094-1102. doi: 10.1111/ddg.14294_g.
3
[Prevalence and influencing factors of chronic wounds among clients of home care services in Germany].[德国居家护理服务客户中慢性伤口的患病率及影响因素]
Z Evid Fortbild Qual Gesundhwes. 2019 Mar;140:14-21. doi: 10.1016/j.zefq.2019.01.001. Epub 2019 Feb 15.
4
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(®) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622).使用手持式介质阻挡放电等离子体发生器(PlasmaDerm(®) VU - 2010)缓解下肢慢性静脉溃疡:一项单中心、双臂、开放、前瞻性、随机对照试验(NCT01415622)的结果
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):148-55. doi: 10.1111/jdv.12490. Epub 2014 Mar 25.
5
Potential cellular targets and antibacterial efficacy of atmospheric pressure non-thermal plasma.大气压非热等离子体的潜在细胞靶标和抗菌功效。
Int J Antimicrob Agents. 2014 Feb;43(2):154-60. doi: 10.1016/j.ijantimicag.2013.08.022. Epub 2013 Oct 1.
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Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial.2 分钟冷等离体氩气在慢性伤口中的成功安全应用:一项随机对照试验的结果。
Br J Dermatol. 2012 Aug;167(2):404-10. doi: 10.1111/j.1365-2133.2012.10923.x. Epub 2012 Jul 10.
7
Evidence-based management strategies for treatment of chronic wounds.慢性伤口治疗的循证管理策略
Eplasty. 2009 Jun 4;9:e19.