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1
Ionophore activity of sarcotoxin I, a bactericidal protein of Sarcophaga peregrina.麻蝇毒素I（一种棕尾别麻蝇的杀菌蛋白）的离子载体活性。
Biochem J. 1985 Jul 15;229(2):453-8. doi: 10.1042/bj2290453.
2
Mode of action of a bactericidal protein induced in the haemolymph of Sarcophaga peregrina (flesh-fly) larvae.在棕尾别麻蝇（肉蝇）幼虫血淋巴中诱导产生的一种杀菌蛋白的作用模式。
Biochem J. 1984 Aug 15;222(1):119-24. doi: 10.1042/bj2220119.
3
Inhibitory effect of sarcotoxin IIA, an antibacterial protein of Sarcophaga peregrina, on growth of Escherichia coli.麻蝇抗菌蛋白麻蝇毒素IIA对大肠杆菌生长的抑制作用。
J Biochem. 1988 Apr;103(4):735-9. doi: 10.1093/oxfordjournals.jbchem.a122337.
4
Purification of sarcotoxin III, a new antibacterial protein of Sarcophaga peregrina.麻蝇毒素III的纯化，麻蝇（Sarcophaga peregrina）的一种新型抗菌蛋白。
J Biochem. 1987 Jul;102(1):69-74. doi: 10.1093/oxfordjournals.jbchem.a122042.
5
Interaction between liposomes and sarcotoxin IA, a potent antibacterial protein of Sarcophaga peregrina (flesh fly).脂质体与麻蝇（肉蝇）的一种强效抗菌蛋白——麻蝇毒素IA之间的相互作用。
J Biol Chem. 1987 Feb 5;262(4):1665-9.
6
Primary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae.麻蝇（肉蝇）幼虫血淋巴中诱导产生的抗菌蛋白——肌毒素I的一级结构。
J Biol Chem. 1985 Jun 25;260(12):7174-7.
7
Purification of Sarcophaga (fleshfly) lectin and detection of sarcotoxins in the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.棕尾别麻蝇凝集素的纯化及棕尾别麻蝇胚胎细胞系NIH-Sape-4培养基中麻蝇毒素的检测
Biochem J. 1987 Nov 15;248(1):217-22. doi: 10.1042/bj2480217.
8
Molecular cloning of a cDNA and assignment of the C-terminal of sarcotoxin IA, a potent antibacterial protein of Sarcophaga peregrina.棕尾别麻蝇一种强效抗菌蛋白——肌毒素IA的cDNA分子克隆及C末端定位
Biochem J. 1986 Nov 1;239(3):717-22. doi: 10.1042/bj2390717.
9
Novel feature of expression of the sarcotoxin IA gene in development of Sarcophaga peregrina.麻蝇肌毒素IA基因在棕尾别麻蝇发育过程中表达的新特征。
Biochem Biophys Res Commun. 1988 Jan 29;150(2):540-4. doi: 10.1016/0006-291x(88)90427-5.
10
Molecular cloning, sequencing, and characterization of cDNA for sarcotoxin IIA, an inducible antibacterial protein of Sarcophaga peregrina (flesh fly).麻蝇（肉蝇）诱导性抗菌蛋白——肌毒素IIA的cDNA的分子克隆、测序及特性分析
Biochemistry. 1988 Mar 8;27(5):1715-21. doi: 10.1021/bi00405a050.

引用本文的文献

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OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria.OMN6：一种用于治疗耐多药革兰氏阴性菌的新型生物工程肽。
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Characterization of the antimicrobial peptide derived from sapecin B, an antibacterial protein of Sarcophaga peregrina (flesh fly).源自麻蝇抗菌蛋白萨佩辛B的抗菌肽的特性分析。 （麻蝇为麻蝇科昆虫的统称，此处麻蝇学名Sarcophaga peregrina 直译为“棕尾别麻蝇” ）
Biochem J. 1994 Mar 15;298 Pt 3(Pt 3):623-8. doi: 10.1042/bj2980623.
4
Molecular cloning of a cDNA and assignment of the C-terminal of sarcotoxin IA, a potent antibacterial protein of Sarcophaga peregrina.棕尾别麻蝇一种强效抗菌蛋白——肌毒素IA的cDNA分子克隆及C末端定位
Biochem J. 1986 Nov 1;239(3):717-22. doi: 10.1042/bj2390717.
5
Magainins and the disruption of membrane-linked free-energy transduction.蛙皮抗菌肽与膜联自由能转导的破坏
Proc Natl Acad Sci U S A. 1989 Sep;86(17):6597-601. doi: 10.1073/pnas.86.17.6597.
6
Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.导入平面脂质膜的天蚕素及相关模型化合物的通道形成特性。
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5072-6. doi: 10.1073/pnas.85.14.5072.
7
The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.果蝇中的杀菌肽基因座；一个参与感染反应的紧密基因簇。
EMBO J. 1990 Jan;9(1):217-24. doi: 10.1002/j.1460-2075.1990.tb08098.x.
8
Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo.β-内酰胺类抗生素在体外和体内均能增强蛙皮抗菌肽2的抗菌活性。
Antimicrob Agents Chemother. 1991 Jun;35(6):1153-9. doi: 10.1128/AAC.35.6.1153.
9
Pore-forming peptide of pathogenic Entamoeba histolytica.致病性溶组织内阿米巴的成孔肽。
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7659-63. doi: 10.1073/pnas.88.17.7659.

本文引用的文献

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Insect immunity. Isolation and sequence of two cDNA clones corresponding to acidic and basic attacins from Hyalophora cecropia.昆虫免疫。来自天蚕蛾属 Hyalophora cecropia 的酸性和碱性 attacins 的两个 cDNA 克隆的分离和序列。
EMBO J. 1984 Sep;3(9):2071-5. doi: 10.1002/j.1460-2075.1984.tb02093.x.
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Insect immunity. The primary structure of the antibacterial protein attacin F and its relation to two native attacins from Hyalophora cecropia.昆虫免疫。抗菌蛋白 attacin F 的一级结构及其与 Hyalophora cecropia 两种天然 attacin 的关系。
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Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.昆虫免疫：从天蚕蛹中分离出杀菌肽D及四种次要抗菌成分并解析其结构
Eur J Biochem. 1982 Sep;127(1):207-17. doi: 10.1111/j.1432-1033.1982.tb06857.x.
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Purification and characterization of an antibacterial protein from haemolymph of Sarcophaga peregrina (flesh-fly) larvae.棕尾别麻蝇（肉蝇）幼虫血淋巴中一种抗菌蛋白的纯化与特性分析
Biochem J. 1983 Jun 1;211(3):727-34. doi: 10.1042/bj2110727.
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Seminalplasmin inhibits transcription and translation of phi80 DNA in vitro.精液纤溶酶在体外抑制φ80 DNA的转录和翻译。
FEBS Lett. 1983 Feb 7;152(1):6-10. doi: 10.1016/0014-5793(83)80470-0.
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Effects of hemolymph from immune and non-immune larvae of Galleria mellonella on the ultra-structure of Pseudomonas aeruginosa.米蛾免疫和非免疫幼虫血淋巴对铜绿假单胞菌超微结构的影响
Dev Comp Immunol. 1982 Summer;6(3):433-40. doi: 10.1016/s0145-305x(82)80029-3.
7
Antibacterial peptide from normal rabbit serum. 3. Inhibition of microbial electron transport.来自正常兔血清的抗菌肽。3. 对微生物电子传递的抑制作用。
Biochemistry. 1981 Oct 13;20(21):5988-94. doi: 10.1021/bi00524a010.
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Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages.兔肺巨噬细胞天然肽抗生素MCP - 1和MCP - 2的一级结构
J Biol Chem. 1983 Dec 10;258(23):14485-9.
9
Mode of action of a bactericidal protein induced in the haemolymph of Sarcophaga peregrina (flesh-fly) larvae.在棕尾别麻蝇（肉蝇）幼虫血淋巴中诱导产生的一种杀菌蛋白的作用模式。
Biochem J. 1984 Aug 15;222(1):119-24. doi: 10.1042/bj2220119.
10
Bactericidal and bacteriolytic activity of serum against gram-negative bacteria.血清对革兰氏阴性菌的杀菌和溶菌活性。
Microbiol Rev. 1983 Mar;47(1):46-83. doi: 10.1128/mr.47.1.46-83.1983.

麻蝇毒素I（一种棕尾别麻蝇的杀菌蛋白）的离子载体活性。

Ionophore activity of sarcotoxin I, a bactericidal protein of Sarcophaga peregrina.

作者信息

Okada M, Natori S

出版信息

Biochem J. 1985 Jul 15;229(2):453-8. doi: 10.1042/bj2290453.

DOI:10.1042/bj2290453
PMID:3899107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145077/
Abstract

When Escherichia coli was treated with sarcotoxin I, a potent bactericidal protein of Sarcophaga peregrina (fleshfly), K+ inside of the cells leaked out rapidly and the ATP pool of the cells rapidly decreased. These results suggested that the bactericidal effect of sarcotoxin I was due to its ionophore activity, and that it blocked the generation of ATP by inhibiting formation of the proton gradient essential for oxidative phosphorylation. This was confirmed by use of an uncA mutant, which was much less susceptible than the wild-type strain to sarcotoxin I under fixed ionic conditions.

摘要

当用麻蝇毒素I（一种棕尾别麻蝇的强效杀菌蛋白）处理大肠杆菌时，细胞内的K+迅速泄漏，细胞的ATP池迅速减少。这些结果表明，麻蝇毒素I的杀菌作用归因于其离子载体活性，并且它通过抑制氧化磷酸化所必需的质子梯度的形成来阻断ATP的生成。使用uncA突变体证实了这一点，在固定离子条件下，该突变体比野生型菌株对麻蝇毒素I的敏感性低得多。