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在棕尾别麻蝇（肉蝇）幼虫血淋巴中诱导产生的一种杀菌蛋白的作用模式。

Mode of action of a bactericidal protein induced in the haemolymph of Sarcophaga peregrina (flesh-fly) larvae.

作者信息

Okada M, Natori S

出版信息

Biochem J. 1984 Aug 15;222(1):119-24. doi: 10.1042/bj2220119.

DOI:10.1042/bj2220119
PMID:6383355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144151/
Abstract

The mode of action of a bactericidal protein (sarcotoxin I) purified from the haemolymph of Sarcophaga peregrina (flesh-fly) larvae was studied, focusing attention on its effect on the function of the membrane of Escherichia coli. Sarcotoxin I almost completely blocked the uptakes of tetraphenylphosphonium ion and proline, which are known to be driven by a membrane potential, indicating that this protein disrupts the membrane potential of bacteria.

摘要

对从棕尾别麻蝇（肉蝇）幼虫血淋巴中纯化得到的一种杀菌蛋白（肌毒素I）的作用模式进行了研究，重点关注其对大肠杆菌细胞膜功能的影响。肌毒素I几乎完全阻断了四苯基鏻离子和脯氨酸的摄取，已知这两种物质的摄取是由膜电位驱动的，这表明该蛋白破坏了细菌的膜电位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/1144151/268c656b0570/biochemj00321-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/1144151/268c656b0570/biochemj00321-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/1144151/268c656b0570/biochemj00321-0124-a.jpg

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