Wei Xiao-Xue, Zhao Zhen-Zhen, Pang Xiaobo, Shu Xing-Zhong
State Key Laboratory of Applied Organic Chemistry (SKLAOC), College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, China.
Org Lett. 2024 Jul 26;26(29):6125-6129. doi: 10.1021/acs.orglett.4c01897. Epub 2024 Jul 12.
The reductive C-Si coupling of chlorosilanes offers efficient access to organosilanes, but its potential for constructing aliphatic ones remains largely unexplored. This manuscript presents a nickel-catalyzed Csp-Si coupling reaction of unactivated alkyl-Br and RSi(H)Cl. This work establishes a new approach for synthesizing highly functionalized aliphatic hydrosilanes from readily available chemical feedstocks. The reaction is easily scalable and can accommodate various functional groups, including carboxylic acids, which are usually incompatible with basic conditions.
氯硅烷的还原碳-硅偶联反应为制备有机硅烷提供了有效途径，但其构建脂肪族有机硅烷的潜力在很大程度上仍未得到探索。本论文介绍了一种镍催化的未活化烷基溴与RSi(H)Cl的Csp-硅偶联反应。这项工作建立了一种从易得的化学原料合成高官能化脂肪族氢硅烷的新方法。该反应易于扩大规模，并且能够兼容各种官能团，包括通常与碱性条件不相容的羧酸。
