Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
Cells. 2024 Jun 24;13(13):1093. doi: 10.3390/cells13131093.
Although more difficult to detect than in the cytoplasm, it is now clear that actin polymerization occurs in the nucleus and that it plays a role in the specific processes of the nucleus such as transcription, replication, and DNA repair. A number of studies suggest that nuclear actin polymerization is promoting precise DNA repair by homologous recombination, which could potentially be of help for precise genome editing and gene therapy. This review summarizes the findings and describes the challenges and chances in the field.
虽然核内肌动蛋白聚合比细胞质中更难检测，但现在已经清楚，肌动蛋白聚合发生在核内，并在转录、复制和 DNA 修复等核内特定过程中发挥作用。许多研究表明，核内肌动蛋白聚合通过同源重组促进精确的 DNA 修复，这对于精确的基因组编辑和基因治疗可能有帮助。本文综述了这方面的研究结果，并描述了该领域的挑战和机遇。
