Haghdoost Mehdi, Peters Erica N, Roberts Matthew, Bonn-Miller Marcel O
Nalu Bio Inc, San Francisco, California, USA.
Emerald Mountain Consulting, LLC, Charlottesville, Virginia, USA.
Cannabis Cannabinoid Res. 2025 Feb;10(1):1-5. doi: 10.1089/can.2024.0051. Epub 2024 Jul 12.
Tetrahydrocannabivarin (THCV) is a phytocannabinoid that is becoming popular across the North American cannabis market. THCV has been reported to reduce blood sugar and act as an appetite suppressant in several independent pre-clinical studies, which has earned it the popular nickname of "diet weed," despite few human studies of these effects. Additionally, THCV is usually and incorrectly categorized as an intoxicating analogue of tetrahydrocannabinol (THC), which causes confusion among both consumers and regulators. In this article, we examine what is known pre-clinically and clinically about THCV, as well as highlight mechanisms of action, in order to clarify the scientific differences between THCV and THC. THCV, although structurally similar to THC, has distinct pharmacological activity and physiological effects at the doses currently reported in the literature. We highlight areas of opportunity for further THCV research in order to determine the full and appropriate potential for unique health, wellness, and therapeutic applications of this compound.
四氢大麻酚酸（THCV）是一种植物大麻素，在北美大麻市场上越来越受欢迎。在几项独立的临床前研究中，THCV被报道可降低血糖并起到食欲抑制剂的作用，尽管对这些作用的人体研究很少，但它还是因此获得了“减肥大麻”这个流行的昵称。此外，THCV通常被错误地归类为四氢大麻酚（THC）的致醉类似物，这在消费者和监管机构中都造成了混淆。在本文中，我们研究了临床前和临床方面关于THCV的已知情况，并强调其作用机制，以阐明THCV和THC之间的科学差异。THCV虽然在结构上与THC相似，但在目前文献报道的剂量下具有独特的药理活性和生理效应。我们强调了THCV进一步研究的机会领域，以确定这种化合物在独特的健康、保健和治疗应用方面的全部和适当潜力。
