Ibanez Agustin, Slachevsky Andrea
Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago, Chile.
Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Nat Rev Neurol. 2024 Oct;20(10):571-572. doi: 10.1038/s41582-024-00998-0.
Current dementia research has developed complex models of environmental-genetic interactions to better address the multimodal disease phenotypes. New evidence highlights a stronger impact of social determinants of health than ancestry effects specific to Latin America, opening new agendas to address the multimodal diversity of environmental-genetics interactions in aging and dementia.
当前的痴呆症研究已经开发出复杂的环境-基因相互作用模型，以更好地应对多模式疾病表型。新证据表明，健康的社会决定因素比拉丁美洲特有的血统效应影响更大，这为解决衰老和痴呆症中环境-基因相互作用的多模式多样性开辟了新的议程。
