Fmoc 固相肽合成。

Fmoc Solid-Phase Peptide Synthesis.

机构信息

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

, Måløv, Denmark.

出版信息

Methods Mol Biol. 2024;2821:33-55. doi: 10.1007/978-1-0716-3914-6_3.

DOI:10.1007/978-1-0716-3914-6_3

PMID:38997478

Abstract

Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. Here, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.

摘要

合成肽在药物和研究中都很重要。目前，生产这些化合物的首选方法是固相肽合成。在这里，我们描述了 Fmoc 固相肽合成的范围和局限性。此外，我们还提供了 Fmoc 肽合成的详细方案。