Pharma Foods International Co., Ltd., Kyoto 615-8245, Japan.
Nutrients. 2024 Jul 1;16(13):2100. doi: 10.3390/nu16132100.
Our search for plant-derived ceramides from sustainable sources led to the discovery of ceramides and glucosylceramides in wine lees.
This study evaluated the efficacy and safety of wine lees extract (WLE)-derived ceramides and glucosylceramides in enhancing skin barrier function.
A randomized, double-blind, placebo-controlled study was conducted with 30 healthy Japanese subjects aged 20-64. Subjects were allocated to receive either the WLE-derived ceramides and glucosylceramides (test group) or placebo for 12 weeks. The primary outcome was transepidermal water loss (TEWL), and secondary outcomes included skin hydration, visual analog scale (VAS) of itching sensation, and the Japanese Skindex-29.
One participant withdrew for personal reasons, resulting in 29 subjects for data analysis (placebo = 15; test = 14). The test group showed a tendency of lower TEWL compared to the placebo after 8 weeks ( = 0.07). Furthermore, after 12 weeks of administration, the test group had significantly lower TEWL than the placebo ( = 0.04). On the other hand, no significant differences were observed in the secondary outcome parameters. No adverse events related to the supplements were reported.
Oral supplementation of WLE-derived ceramides and glucosylceramides is a prominent and safe approach to enhancing skin barrier function and health.
(UMIN000050422).
我们从可持续来源中寻找植物衍生的神经酰胺，从而在酒渣中发现了神经酰胺和葡糖基神经酰胺。
本研究评估了酒渣提取物（WLE）衍生的神经酰胺和葡糖基神经酰胺增强皮肤屏障功能的功效和安全性。
一项随机、双盲、安慰剂对照研究纳入了 30 名 20-64 岁的健康日本受试者。受试者被分配接受 WLE 衍生的神经酰胺和葡糖基神经酰胺（试验组）或安慰剂治疗 12 周。主要结局指标为经表皮水分丢失（TEWL），次要结局指标包括皮肤水分含量、瘙痒视觉模拟量表（VAS）评分和日本 Skindex-29。
1 名受试者因个人原因退出，最终 29 名受试者纳入数据分析（安慰剂组 = 15 例；试验组 = 14 例）。与安慰剂组相比，试验组在 8 周后 TEWL 有降低的趋势（ = 0.07）。此外，在给药 12 周后，试验组的 TEWL 显著低于安慰剂组（ = 0.04）。另一方面，次要结局参数未见显著差异。未报告与补充剂相关的不良反应。
口服 WLE 衍生的神经酰胺和葡糖基神经酰胺是增强皮肤屏障功能和健康的一种显著且安全的方法。
（UMIN000050422）。
