Research Scientist, No. 14A, KIADB, R & D Center for Excellence, Vidya Herbs (P) Ltd., Jigani Industrial Area, Bangalore, Anekal Taluk, 560 105, India.
BMC Complement Med Ther. 2020 Jan 31;20(1):26. doi: 10.1186/s12906-019-2721-3.
Ceramides play a fundamental role in maintaining the skin health as a function of improved barrier permeability. Reduced ceramide content results in skin dryness and wrinkledness. Intake of dietary ceramides potentially compensates the skin ceramide content. In the present study we have assessed the skin health benefits of oral supplementation of a hydroalcoholic extract from Amorphophallus konjac tubers standardized to 5% glycosylceramides, in a placebo-controlled clinical trial.
Fifty-one healthy human volunteers (aged 18-60 years) were supplemented with 100 mg/day of either a placebo or A. konjac extract capsules (5 mg glycosylceramides) for 6-weeks. The skin parameters were evaluated through dermatological diagnosis. Subject perceived efficacy of the product was further evaluated by a self-assessment questionnaire.
Oral intake of A. konjac extract significantly decreased the skin dryness, hyperpigmentation, redness, itching and oilyness (p < 0.05). The improvement in skin health following intake of A. konjac extract was observed to be time-dependent from the start. Further, A. konjac extract was well-tolerated throughout the study, as no adverse events or toxic changes were recorded.
The study demonstrates the skincare properties of orally ingested glycosyl ceramides from konjac tubers.
CTRI/2018/12/016661 dated 13/12/2018 retrospectively registered, http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=19851&EncHid=&userName=SkinCera.
神经酰胺在改善屏障通透性方面起着维持皮肤健康的基本作用。神经酰胺含量减少会导致皮肤干燥和皱纹。摄入膳食神经酰胺可能会补偿皮肤中的神经酰胺含量。在本研究中，我们评估了口服魔芋根茎水醇提取物（标准化为 5%糖基神经酰胺）对皮肤健康的益处，该提取物在安慰剂对照临床试验中进行了评估。
51 名健康的人类志愿者（年龄 18-60 岁）每天补充 100mg 安慰剂或 A. konjac 提取物胶囊（5mg 糖基神经酰胺），持续 6 周。通过皮肤病学诊断评估皮肤参数。通过自我评估问卷进一步评估产品的主观功效。
口服 A. konjac 提取物可显著降低皮肤干燥、色素沉着、发红、瘙痒和油腻感（p<0.05）。从开始摄入 A. konjac 提取物后，皮肤健康状况的改善呈时间依赖性。此外，在整个研究过程中，A. konjac 提取物均具有良好的耐受性，因为没有记录到不良反应或毒性变化。
该研究表明魔芋根茎中摄入的糖基神经酰胺具有护肤特性。
2018 年 12 月 13 日回顾性注册 CTRI/2018/12/016661，http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=19851&EncHid=&userName=SkinCera。
