Liao Zhiwei, Tong Bide, Ke Wencan, Yang Cao, Wu Xinghuo, Lei Ming
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Mitochondrion. 2024 Sep;78:101935. doi: 10.1016/j.mito.2024.101935. Epub 2024 Jul 11.
In recent years, research has increasingly focused on the biogenesis of extracellular vesicles (EVs) and the sorting mechanisms for their contents. Mitochondria can be selectively loaded into EVs, serving as a way to maintain cellular mitochondrial homeostasis. EV-mediated mitochondrial transfer has also been shown to greatly impact the function of target cells. Based on the mechanism of EV-mediated mitochondrial transfer, therapies can be developed to treat human diseases. This review summarizes the recent advances in the biogenesis and molecular composition of EVs. It also highlights the sorting and trafficking mechanisms of mitochondrial components into EVs. Furthermore, it explores the current role of EV-mediated mitochondrial transfer in the development of human diseases, as well as its diagnostic and therapeutic applications.
近年来，研究越来越集中在细胞外囊泡（EVs）的生物发生及其内容物的分选机制上。线粒体可以被选择性地装载到EVs中，作为维持细胞线粒体稳态的一种方式。EV介导的线粒体转移也已被证明对靶细胞的功能有很大影响。基于EV介导的线粒体转移机制，可以开发治疗人类疾病的疗法。本综述总结了EVs生物发生和分子组成方面的最新进展。它还强调了线粒体成分进入EVs的分选和运输机制。此外，它探讨了EV介导的线粒体转移在人类疾病发展中的当前作用及其诊断和治疗应用。
