School of Life Sciences, Bengbu Medical University, Bengbu, China.
School of Life Sciences, Bengbu Medical University, Bengbu, China.
Int J Biol Macromol. 2024 Oct;277(Pt 1):133830. doi: 10.1016/j.ijbiomac.2024.133830. Epub 2024 Jul 11.
As a natural three-dimensional biopolymer, decellularized plant-derived scaffolds usually comprise various polysaccharides, mostly cellulose, pectin, and hemicellulose. They are characterized by natural biocompatibility and porous structures. The emergence of decellularized purified polysaccharide scaffolds provides an attractive method to overcome the challenges associated with nutrient delivery and biocompatibility, as they serve as optimal non-immune environments for stem cell adhesion and proliferation. To date, limited corresponding literature is available to systemically summarize the development and potential of these scaffolds in tissue engineering. Therefore, the current review summarized the biomimetic properties of plant-derived polysaccharide scaffolds and the latest progress in tissue engineering applications. This review first discusses the advantages of decellularized plant-derived polysaccharide scaffolds by briefly introducing their features and current limitations in clinical applications. Subsequently, the latest progress in emerging applications of regenerative biomaterials is reviewed, followed by a discussion of the studies on the interactions of biomaterials with cells and tissues. Finally, challenges in obtaining reliable scaffolds and possible future directions are discussed.
作为一种天然的三维生物聚合物，脱细胞植物衍生支架通常包含各种多糖，主要是纤维素、果胶和半纤维素。它们的特点是具有天然的生物相容性和多孔结构。脱细胞纯化多糖支架的出现为克服与营养传递和生物相容性相关的挑战提供了一种有吸引力的方法，因为它们是干细胞附着和增殖的最佳非免疫环境。迄今为止，关于这些支架在组织工程中的发展和潜力的相应文献有限。因此，本综述系统总结了植物衍生多糖支架的仿生特性和组织工程应用的最新进展。本综述首先通过简要介绍其特征和当前在临床应用中的局限性，讨论了脱细胞植物衍生多糖支架的优势。随后，综述了再生生物材料的最新应用进展，接着讨论了生物材料与细胞和组织相互作用的研究。最后，讨论了获得可靠支架的挑战和可能的未来方向。
