Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu Province 225300, China; College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province 225009, China.
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province 225009, China.
Poult Sci. 2024 Sep;103(9):104025. doi: 10.1016/j.psj.2024.104025. Epub 2024 Jun 26.
Free gossypol (FG), the primary antinutritional component in cottonseed meal, can adversely affect the growth and health of poultry. Although younger geese are particularly sensitive to FG, the precise effects of FG on geese remain elusive. This study aimed to investigate the effects of gossypol acetate (GA), a form of FG, on the growth, serum biochemical parameters, and intestinal health of goslings. Seventy-two healthy male goslings, aged 7-day-old with similar body weight (BW), were randomly divided into 3 groups: a control group and 2 GA-treated groups (GA25 and GA50), which were orally administered GA (25 and 50 mg/kg BW) daily for 14 d. The results showed that oral administration of GA significantly suppressed BW, altered serum parameters, and impaired intestinal health in a dose- and time-dependent manner. Specifically, GA adversely affected intestinal morphology, induced oxidative stress, and inflammation, diminished immune function, and increased intestinal permeability and apoptosis of intestinal cells, consequently impairing nutrient absorption and utilization of goslings. Overall, these data indicate that GA adversely affects the growth, serum parameters, and intestinal health of goslings, providing valuable information further to understand the toxic effects of gossypol on goslings.
游离棉酚（FG）是棉籽饼粕中的主要抗营养成分，可对家禽的生长和健康产生不利影响。尽管小鹅对 FG 特别敏感，但 FG 对鹅的确切影响仍不清楚。本研究旨在探讨棉酚乙酸酯（GA），一种 FG 的形式，对雏鹅生长、血清生化参数和肠道健康的影响。72 只 7 日龄、体重相近的健康雄性雏鹅被随机分为 3 组：对照组和 2 个 GA 处理组（GA25 和 GA50），它们分别每天口服 GA（25 和 50mg/kgBW），连续 14 天。结果表明，GA 的口服给药以剂量和时间依赖的方式显著抑制 BW，改变血清参数，并损害肠道健康。具体而言，GA 对肠道形态产生不利影响，诱导氧化应激和炎症，降低免疫功能，增加肠道通透性和肠细胞凋亡，从而损害雏鹅对营养物质的吸收和利用。总的来说，这些数据表明 GA 对雏鹅的生长、血清参数和肠道健康产生不利影响，为进一步了解棉酚对雏鹅的毒性作用提供了有价值的信息。
