Luo Qiyu, Xu Tongxiang, Ainiwaer Zulibina, Fan Wenpeng, Wang Caidie
College of Animal Sciences, Xinjiang Agricultural University, Urumqi, China.
Xinjiang Key Laboratory of Herbivore Nutrition for Meat and Milk, Urumqi, China.
Front Vet Sci. 2025 Apr 15;12:1562325. doi: 10.3389/fvets.2025.1562325. eCollection 2025.
The objective of this study was to determine the effects of biotin on growth performance, serum biochemical profiles, and morphology of acetate gossypol-treated mice. Seventy-five healthy male Kunming mice were randomly assigned to five treatment groups: the control group (C), the biotin control group (BC), the acetate gossypol control group (AGC), the biotin prevention group (BP) and the biotin treatment group (BT). The study examined the growth performance, visceral index, serum biochemical profiles and histomorphological changes of mice. The results showed that compared with AGC group mice, the average daily feed intake of BP group and BT group increased by 40.47 and 45.69% ( 0.05). Biotin prevention reduced the elevated blood urea nitrogen (BUN) levels in acetate gossypol-treated mice, biotin treatment reduced the elevated serum aspartate aminotransferase (AST), total protein (TP) and BUN levels in acetate gossypol-treated mice ( 0.05). Biotin increase the values of villus height/crypt depth in duodenum and jejunum ( 0.05). In conclusion, biotin potentially increase the growth performance of acetate gossypol-treated mice, it also has a positive effect on serum biochemical profiles, and histomorphological of acetate gossypol-treated mice.
本研究的目的是确定生物素对醋酸棉酚处理的小鼠生长性能、血清生化指标和形态学的影响。75只健康雄性昆明小鼠被随机分为五个处理组：对照组（C）、生物素对照组（BC）、醋酸棉酚对照组（AGC）、生物素预防组（BP）和生物素治疗组（BT）。该研究检测了小鼠的生长性能、脏器指数、血清生化指标和组织形态学变化。结果表明，与AGC组小鼠相比，BP组和BT组的平均日采食量分别增加了40.47%和45.69%（P<0.05）。生物素预防降低了醋酸棉酚处理小鼠升高的血尿素氮（BUN）水平，生物素治疗降低了醋酸棉酚处理小鼠升高的血清天冬氨酸转氨酶（AST）、总蛋白（TP）和BUN水平（P<0.05）。生物素增加了十二指肠和空肠绒毛高度/隐窝深度的值（P<0.05）。总之，生物素可能提高醋酸棉酚处理小鼠的生长性能，对醋酸棉酚处理小鼠的血清生化指标和组织形态学也有积极影响。
