Department of Food and Animal Sciences, Alabama A & M University, Huntsville, AL 35762, USA.
Department of Food and Animal Sciences, Alabama A & M University, Huntsville, AL 35762, USA.
Poult Sci. 2024 Sep;103(9):103962. doi: 10.1016/j.psj.2024.103962. Epub 2024 Jun 14.
Active ghrelin (AG) is produced through the post-translational addition of n-octanoic acid to the amino residue Ser-3, making it the natural ligand for the ghrelin receptor. The synthesis of AG is contingent upon specific dietary fatty acids as substrates for the acylation process. Prior studies have demonstrated that AG infusion can lead to reduced feed intake (FI) in broiler chickens, suggesting that manipulating AG may serve as an alternative to quantitative feed restriction in broiler breeders. In this study, we evaluated the effect of dietary sodium octanoate (Octanoate) on FI, water intake (WI), BW, total ghrelin, and β-hydroxybutyrate (BHB) concentration in two avian species. Broiler chickens and turkeys were reared as recommended by the industry. At 3 wk of age, birds were randomly assigned to a 2 × 3 factorial. The first factor included two species (chickens and turkeys), and the second included doses (0, 4, and 8 mg/mL) of Octanoate in drinking water for 30 d. Feed and WI were recorded daily, while body weight and blood samples were obtained weekly. In chickens, Octanoate doses increased ghrelin and BHB concentrations linearly, while FI and BW decreased linearly with rising Octanoate doses (P < 0.05). However, Octanoate doses did not affect ghrelin, BHB, FI, or BW in turkeys. In conclusion, our data indicate that sodium octanoate administration elicits a differential response in feed intake and body weight gain in chickens and turkeys.
活性 ghrelin（AG）是通过在丝氨酸残基 Ser-3 上添加 n-辛酸来进行翻译后修饰而产生的，使其成为 ghrelin 受体的天然配体。AG 的合成取决于特定的膳食脂肪酸作为酰化过程的底物。先前的研究表明，AG 输注可导致肉鸡采食量（FI）降低，这表明操纵 AG 可能是替代肉鸡种鸡定量饲料限制的一种方法。在这项研究中，我们评估了膳食正辛酸（Octanoate）对两种禽类的 FI、水摄入量（WI）、BW、总 ghrelin 和 β-羟基丁酸（BHB）浓度的影响。肉鸡和火鸡按照行业建议进行饲养。在 3 周龄时，将鸟类随机分配到 2×3 因子设计中。第一个因子包括两个物种（鸡和火鸡），第二个因子包括饮用水中 Octanoate 的三个剂量（0、4 和 8 mg/mL），持续 30 天。每天记录饲料和 WI，每周采集体重和血液样本。在鸡中，Octanoate 剂量线性增加 ghrelin 和 BHB 浓度，而 FI 和 BW 则随 Octanoate 剂量的升高而线性降低（P<0.05）。然而，Octanoate 剂量对火鸡的 ghrelin、BHB、FI 或 BW 没有影响。总之，我们的数据表明，正辛酸的给药在鸡和火鸡中对采食量和体重增加产生了不同的反应。
