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急性小脑炎与梗阻性脑积水:法洛四联症手术修复后一种隐匿的神经并发症

Acute Cerebellitis and Obstructive Hydrocephalus: An Unseen Neurological Complication After Surgical Repair for Tetralogy of Fallot.

作者信息

Das Anupam

机构信息

Cardiothoracic Vascular Surgery, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.

出版信息

Cureus. 2024 Jun 14;16(6):e62355. doi: 10.7759/cureus.62355. eCollection 2024 Jun.

DOI:10.7759/cureus.62355
PMID:39006608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246560/
Abstract

Acute cerebellitis with obstructive hydrocephalus post-Tetralogy of Fallot surgery is extremely rare but can present aggressively in pediatric cases. Early diagnosis is critical for prompt medical and surgical intervention. We report a fatal case in a 7-year-old boy post-surgery, where neurological symptoms rapidly progressed, leading to drowsiness and intermittent response to commands. Despite initial computed tomography scans showing no abnormality, subsequent scans revealed cerebellitis and hydrocephalus. Treatment with steroids, antibiotics, and cerebrospinal fluid drainage was unsuccessful, and the condition's etiology remained unclear despite negative serological tests and cultures. This highlights the challenge of diagnosing and treating acute cerebellitis, especially when no specific cause is found and when deterioration is swift. The role of opioids in pediatric patients and their potential association with neurosurgical complications is also discussed, prompting further inquiry into postoperative symptoms and opioid-related risks in susceptible individuals.

摘要

法洛四联症手术后出现急性小脑炎伴梗阻性脑积水极为罕见,但在儿科病例中可能呈侵袭性表现。早期诊断对于及时的药物和手术干预至关重要。我们报告一例7岁男孩术后的致命病例,其神经症状迅速进展,导致嗜睡和对指令的间歇性反应。尽管最初的计算机断层扫描显示无异常,但后续扫描发现了小脑炎和脑积水。使用类固醇、抗生素和脑脊液引流治疗均未成功,尽管血清学检测和培养结果为阴性,但病情的病因仍不清楚。这凸显了诊断和治疗急性小脑炎的挑战,尤其是在未发现特定病因且病情迅速恶化的情况下。还讨论了阿片类药物在儿科患者中的作用及其与神经外科并发症的潜在关联,促使进一步探究易感个体的术后症状和阿片类药物相关风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c7/11246560/b9990af103cc/cureus-0016-00000062355-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c7/11246560/23c61afa1810/cureus-0016-00000062355-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c7/11246560/b9990af103cc/cureus-0016-00000062355-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c7/11246560/23c61afa1810/cureus-0016-00000062355-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c7/11246560/b9990af103cc/cureus-0016-00000062355-i02.jpg

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本文引用的文献

1
Acute Cerebellitis in Children: A Variable Clinical Entity.儿童急性小脑炎:一种临床症状多变的病症。
J Child Neurol. 2018 Sep;33(10):675-684. doi: 10.1177/0883073818777673. Epub 2018 Jun 11.
2
Complicated acute cerebellitis with obstructive hydrocephalus and tonsillar herniation in a child.一名儿童患有伴有梗阻性脑积水和扁桃体疝的复杂性急性小脑炎。
BMJ Case Rep. 2017 Apr 26;2017:bcr-2017-219337. doi: 10.1136/bcr-2017-219337.
3
Acute cerebellitis in paediatric patients: Our experience.小儿急性小脑炎:我们的经验
Neurologia (Engl Ed). 2019 Jun;34(5):291-299. doi: 10.1016/j.nrl.2017.01.006. Epub 2017 Mar 18.
4
Opioid overdose in a child: case report and discussion with emphasis on neurosurgical implications.儿童阿片类药物过量:病例报告及讨论,重点关注神经外科方面的影响
J Neurosurg Pediatr. 2015 Dec;16(6):752-7. doi: 10.3171/2015.4.PEDS14667. Epub 2015 Sep 4.
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Cerebellitis and acute obstructive hydrocephalus associated with Mycoplasma pneumoniae infection.
Pediatr Infect Dis J. 2014 May;33(5):529-32. doi: 10.1097/INF.0000000000000140.