Hospital Clínico Universitario, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain.
Hospital Universitario de Jaén, Jaén, Spain.
Clin Transl Oncol. 2024 Nov;26(11):2758-2770. doi: 10.1007/s12094-024-03531-3. Epub 2024 Jul 15.
In recent years, the incorporation of new strategies to the therapeutic armamentarium has completely changed the outcomes of epithelial ovarian cancer (EOC). The identification of new predictive and prognostic biomarkers has also enabled the selection of those patients more likely to respond to targeted agents. Nevertheless, EOC is still a highly lethal disease and resistance to many of these new agents is common. The objective of this guideline is to summarize the most relevant strategies to manage EOC, to help the clinician throughout the challenging diagnostic and therapeutic processes and to provide evidence-based recommendations.
近年来,新策略的引入彻底改变了上皮性卵巢癌(EOC)的治疗结果。新的预测和预后生物标志物的鉴定也使得选择那些更有可能对靶向药物产生反应的患者成为可能。然而,EOC 仍然是一种高度致命的疾病,对许多这些新药物的耐药性很常见。本指南的目的是总结管理 EOC 的最相关策略,帮助临床医生应对具有挑战性的诊断和治疗过程,并提供基于证据的建议。