通过邻苯二胺与芳基乙酸酯的氧化偶联反应实现硫促进的3-芳基喹喔啉-2-酮的合成
Sulfur-Promoted Access to 3-Arylquinoxalin-2-ones by Oxidative Coupling of -Phenylenediamines with Arylacetates.
作者信息
Nguyen Le Anh, Tran Thi Yen, Ngo Quoc Anh, Mac Dinh Hung, Retailleau Pascal, Nguyen Thanh Binh
机构信息
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Cau Giay, Hanoi, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Cau Giay, Hanoi, Vietnam.
出版信息
Org Lett. 2024 Jul 26;26(29):6098-6102. doi: 10.1021/acs.orglett.4c01624. Epub 2024 Jul 15.
We disclose the synthesis of 3-arylquinoxalin-2-ones from -phenylenediamines and readily available arylacetates. The method harnesses the selective oxidative property of elemental sulfur in the presence of amine base catalyst and DMSO. The reactions are operationally simple and tolerate a wide range of functional groups.
我们公开了一种由对苯二胺和易得的芳基乙酸酯合成3-芳基喹喔啉-2-酮的方法。该方法利用了在胺碱催化剂和二甲基亚砜存在下元素硫的选择性氧化特性。这些反应操作简单，并且能耐受多种官能团。
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