Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, Zunyi, 563000, China.
Sci Rep. 2024 Jul 15;14(1):16316. doi: 10.1038/s41598-024-67336-8.
The objective of this study was to evaluate semi-quantitatively the diagnostic performance of PET/CT metabolic parameters in differentiating benign or malignant cardiac or pericardial masses. A total of forty-one patients with newly diagnosed cardiac/pericardial masses who underwent F-FDG PET/CT were recruited. PET/CT metabolic parameters including the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), total lesion glycolysis (TLG), tumor metabolic volume (MTV), the maximum tumor-to-mediastinal background ratio (TMR) and the maximum tumor-to-liver background ratio (TLR) is measured or calculated to evaluate the benign or malignant nature of cardiac/pericardial masses. Compared with benign cardiac/pericardial lesions, cardiac/pericardial malignancies had higher SUVmax, SUVmean, TLG, MTV, TMR, and TLR. All these PET/CT metabolic parameters showed high diagnostic performance in semi-quantitative evaluation of benign or malignant cardiac or pericardial masses, and SUVmean and MTV had the highest diagnostic accuracy. Therefore, PET/CT metabolic parameters can semi-quantitatively evaluate the benign or malignant cardiac/pericardial masses.
本研究旨在评估 PET/CT 代谢参数对半定量区分心脏或心包良恶性肿块的诊断性能。共招募了 41 例新诊断为心脏/心包肿块的患者进行 F-FDG PET/CT 检查。测量或计算 PET/CT 代谢参数，包括最大标准化摄取值（SUVmax）、平均标准化摄取值（SUVmean）、总病变糖酵解（TLG）、肿瘤代谢体积（MTV）、最大肿瘤-纵隔背景比（TMR）和最大肿瘤-肝脏背景比（TLR），以评估心脏/心包肿块的良恶性。与良性心脏/心包病变相比，心脏/心包恶性肿瘤的 SUVmax、SUVmean、TLG、MTV、TMR 和 TLR 均较高。所有这些 PET/CT 代谢参数在半定量评估心脏或心包良恶性肿块方面均具有较高的诊断性能，SUVmean 和 MTV 具有最高的诊断准确性。因此，PET/CT 代谢参数可对半定量评估心脏/心包良恶性肿块。
