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使用D.的极性提取物合成的植物功能化氧化锌纳米颗粒的光催化和生物学应用

Photo-catalytic and biological applications of phyto-functionalized zinc oxide nanoparticles synthesized using a polar extract of D.

作者信息

Assad Nasir, Abbas Azhar, Fayyaz Ur Rehman Muhammad, Naeem-Ul-Hassan Muhammad

机构信息

Institute of Chemistry, University of Sargodha Sargodha 40100 Pakistan

Department of Chemistry, Government Ambala Muslim College Sargodha 40100 Pakistan.

出版信息

RSC Adv. 2024 Jul 15;14(31):22344-22358. doi: 10.1039/d4ra03573a. eCollection 2024 Jul 12.

Abstract

In this study, zinc oxide nanoparticles (ZnO NPs) were fabricated using D extract and their diverse properties and applications were studied. Phytochemical analysis confirmed the presence of phenols and flavonoids in the plant extract, playing a crucial role in the stabilization and reduction of the synthesized nanoparticles. The greenly synthesized ZnO NPs were characterized through a range of analytical techniques. UV-visible spectrophotometry has been employed to investigate their optical characteristics. FTIR spectroscopy was employed to identify the functional groups responsible for the synthesis of the ZnO NPs. The structural properties were evaluated using XRD. The morphology and size distribution of the synthesized NPs were examined using SEM, DLS, and elemental spectra evaluated using EDX. The charge that develops at the interface was analyzed using zeta potential which accounts for stability of the NPs. The ZnO NPs exhibited excellent photocatalytic degradation of cationic (methylene blue), anionic (methyl orange), and nonionic (-nitrophenol) dyes under sunlight exposure with photocatalytic degradation of 85.61%, 79.10%, and 89.95% respectively. Additionally, the nanoparticles displayed antimicrobial activity against Gram-positive and Gram-negative bacteria, and noteworthy antioxidant potential. The anti-inflammatory activity of the ZnO NPs, attributed to their ability to inhibit protein denaturation, was dose-dependent. Overall, our findings highlight the versatile properties of the greenly synthesized ZnO NPs, showcasing their potential in environmental remediation, and antimicrobial formulations, and as promising candidates for further exploration in the biomedical fields, including drug delivery and therapeutics.

摘要

在本研究中,使用D提取物制备了氧化锌纳米颗粒(ZnO NPs),并对其多种性质和应用进行了研究。植物化学分析证实植物提取物中存在酚类和黄酮类化合物,它们在合成纳米颗粒的稳定和还原过程中起着关键作用。通过一系列分析技术对绿色合成的ZnO NPs进行了表征。采用紫外可见分光光度法研究其光学特性。利用傅里叶变换红外光谱(FTIR)来识别负责ZnO NPs合成的官能团。使用X射线衍射(XRD)评估其结构性质。利用扫描电子显微镜(SEM)、动态光散射(DLS)对合成的纳米颗粒的形态和尺寸分布进行了检测,并使用能量散射X射线光谱(EDX)评估了元素光谱。利用zeta电位分析了在界面处产生的电荷,这决定了纳米颗粒的稳定性。ZnO NPs在阳光照射下对阳离子(亚甲基蓝)、阴离子(甲基橙)和非离子(对硝基苯酚)染料表现出优异的光催化降解性能,光催化降解率分别为85.61%、79.10%和89.95%。此外,这些纳米颗粒对革兰氏阳性和革兰氏阴性细菌均显示出抗菌活性,以及显著的抗氧化潜力。ZnO NPs的抗炎活性归因于其抑制蛋白质变性的能力,且具有剂量依赖性。总体而言,我们的研究结果突出了绿色合成的ZnO NPs的多功能性质,展示了它们在环境修复、抗菌制剂方面的潜力,以及作为生物医学领域(包括药物递送和治疗)进一步探索的有前途的候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5901/11247436/3f946450858b/d4ra03573a-f1.jpg

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