维生素D补充剂对多囊卵巢综合征女性代谢参数的影响：一项随机对照试验。
Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial.
作者信息
Wen Xinling, Wang Li, Li Fen, Yu Xuewen
机构信息
Department of Anesthesiology and Operation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
出版信息
J Ovarian Res. 2024 Jul 16;17(1):147. doi: 10.1186/s13048-024-01473-6.
OBJECTIVE
The aim of this study was to explore the effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome (PCOS).
METHODS
A total of 60 PCOS women with vitamin D deficiency or insufficiency were enrolled in this randomized controlled trial. Participants were randomized to vitamin D group (2000 IU/day) or control group. The observational parameters were measured at baseline and after treatment, including body mass index (BMI), waist to hip ratio (WHR), oral glucose tolerance test (OGTT) and insulin release test, and lipid metabolism parameters.
RESULTS
The serum 25(OH)D concentrations at different time points after vitamin D supplementation were significantly higher than that in control group (P < 0.05). The BMI, WHR, insulin concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations in women of Vitamin D group after 12 weeks of treatment were significantly lower than that in women of control group (P < 0.05). The serum insulin concentrations and HOMA-IR at different time points of OGTT, serum TG, TC and LDL-C concentrations in women of vitamin D group (obesity) were significantly lower compared with control group (obesity) (P < 0.05). The BMI, WHR, TG, TC and LDL-C concentration in women of vitamin D group (IR) were significantly lower compared with control group (IR) (P < 0.05). No significant difference was observed in metabolic parameters between vitamin D group (non-obesity) and control group (non-obesity) (P > 0.05), and these differences of metabolic parameters were also not observed between vitamin D group (non-IR) and control group (non-IR) (P > 0.05).
CONCLUSION
Vitamin D supplementation had beneficial effects on metabolic parameters in PCOS women, especially in women with obesity or insulin resistance.
目的
本研究旨在探讨补充维生素D对多囊卵巢综合征（PCOS）女性代谢参数的影响。
方法
本随机对照试验共纳入60例维生素D缺乏或不足的PCOS女性。参与者被随机分为维生素D组（2000 IU/天）和对照组。在基线和治疗后测量观察参数，包括体重指数（BMI）、腰臀比（WHR）、口服葡萄糖耐量试验（OGTT）和胰岛素释放试验以及脂质代谢参数。
结果
补充维生素D后不同时间点的血清25(OH)D浓度显著高于对照组（P < 0.05）。治疗12周后，维生素D组女性的BMI、WHR、胰岛素浓度、胰岛素抵抗稳态模型评估（HOMA-IR）、甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）浓度显著低于对照组女性（P < 0.05）。维生素D组（肥胖）女性在OGTT不同时间点的血清胰岛素浓度和HOMA-IR、血清TG、TC和LDL-C浓度与对照组（肥胖）相比显著降低（P < 0.05）。维生素D组（胰岛素抵抗）女性的BMI、WHR、TG、TC和LDL-C浓度与对照组（胰岛素抵抗）相比显著降低（P < 0.05）。维生素D组（非肥胖）和对照组（非肥胖）之间代谢参数无显著差异（P > 0.05），维生素D组（非胰岛素抵抗）和对照组（非胰岛素抵抗）之间也未观察到这些代谢参数的差异（P > 0.05）。
结论
补充维生素D对PCOS女性的代谢参数有有益影响，尤其是对肥胖或胰岛素抵抗的女性。
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