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中国新冠疫情期间重症脑型疟疾患者的治疗:一例报告

Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China: A case report.

作者信息

Zhu Yan-Fang, Xia Wen-Jing, Liu Wei, Xie Ju-Min

机构信息

Department of Critical Care Medicine, Huangshi Hospital of TCM (Infectious Disease Hospital), Huangshi 435000, Hubei Province, China.

Hubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Huangshi 435003, Hubei Province, China.

出版信息

World J Clin Cases. 2024 Jul 16;12(20):4419-4426. doi: 10.12998/wjcc.v12.i20.4419.

DOI:10.12998/wjcc.v12.i20.4419
PMID:39015931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11235524/
Abstract

BACKGROUND

On June 30, 2021, China received certification from the World Health Organization for malaria elimination. However, this certification does not signify the absence of malaria within China. Due to the increasing frequency of international exchanges and collaborations, the threat of imported malaria persists in China. Consequently, the prevention and control of imported malaria have become a primary focus for our country to maintain its malaria elimination status.

CASE SUMMARY

Herein, we present a case report of a 53-year-old Chinese man who worked in Africa for nearly two years. He was diagnosed with malaria in the Democratic Republic of the Congo between November 19 and November 23, 2022. After receiving effective treatment with oral antimalarial drugs, his condition improved, allowing him to return to China. He was later admitted to our hospital on January 12, 2023, during the coronavirus disease 2019 pandemic in Huangshi, China. Through a thorough evaluation of the patient's symptoms, clinical signs, imaging and laboratory test results, and epidemiological data, he was rapidly diagnosed with severe cerebral malaria. The patient underwent successful treatment through a series of intensive care unit interventions.

CONCLUSION

The successful treatment of this imported case of severe cerebral malaria provides a valuable reference for managing patients with similar malaria infections and has significant clinical implications.

摘要

背景

2021年6月30日,中国获得世界卫生组织消除疟疾认证。然而,这一认证并不意味着中国境内不存在疟疾。由于国际交流与合作日益频繁,中国面临输入性疟疾的威胁依然存在。因此,预防和控制输入性疟疾已成为我国维持消除疟疾状态的首要重点。

病例摘要

在此,我们报告一例53岁中国男性病例,他在非洲工作了近两年。2022年11月19日至11月23日期间,他在刚果民主共和国被诊断为疟疾。在接受口服抗疟药物有效治疗后,他的病情有所改善,得以回国。2023年1月12日,在2019年冠状病毒病疫情期间,他在中国黄石被收治入院。通过对患者症状、临床体征、影像学和实验室检查结果以及流行病学数据的全面评估,他被迅速诊断为重症脑型疟疾。该患者通过一系列重症监护病房干预措施获得成功治疗。

结论

该例输入性重症脑型疟疾的成功治疗为管理类似疟疾感染患者提供了有价值的参考,具有重要的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0305/11235524/e351e6d66fe9/WJCC-12-4419-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0305/11235524/13d58b1d6889/WJCC-12-4419-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0305/11235524/e351e6d66fe9/WJCC-12-4419-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0305/11235524/13d58b1d6889/WJCC-12-4419-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0305/11235524/e351e6d66fe9/WJCC-12-4419-g002.jpg

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Pathogenetic mechanisms and treatment targets in cerebral malaria.脑型疟疾的发病机制与治疗靶点
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