Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
J Affect Disord. 2024 Oct 1;362:623-629. doi: 10.1016/j.jad.2024.07.036. Epub 2024 Jul 15.
Depression is a significant mental health concern, and the ubiquitous presence of fast-food in modern diets raises questions about its impact on mental well-being. Understanding the intricate relationship between fast-food consumption, obesity, and depression is essential for addressing the complex web of factors contributing to this public health issue.
In this study, we analyzed data from the National Health and Nutritional Examination Surveys (NHANES) spanning from 2008 to 2018, involving 31,460 participants.
Among the 31,460 subjects in the survey, 2871 exhibited signs of depression, with an average age of 48.2 years. Each additional weekly fast-food meal was linked to 4 % higher odds of depression, with consuming over two such meals increasing the odds by 24 %. Adjusted models exploring the relationship between body mass index (BMI), fast-food consumption, and depression indicated an increased risk with greater fast-food intake, especially within subgroups based on obesity status. Mediation analysis revealed that fast-food consumption and depression were largely independent of obesity, with obesity accounting for only 6.5 % of the total effect. No significant mediation effect was found in the overweight subgroup, but the mediated effect was increased with higher BMI in more obese patients, notably in those with BMI ≥ 30 or ≥40. Sensitivity analysis confirmed these findings with more conservative estimates across all subgroups.
This study highlights a substantial connection between fast-food consumption and depression. While obesity plays a role, it does not fully mediate the relationship, suggesting the presence of other contributing factors.
抑郁症是一个严重的心理健康问题，而快餐在现代饮食中的普遍存在引发了人们对其对心理健康影响的关注。了解快餐消费、肥胖和抑郁症之间的复杂关系对于解决导致这一公共卫生问题的复杂因素至关重要。
本研究分析了 2008 年至 2018 年期间国家健康和营养检查调查（NHANES）的数据，涉及 31460 名参与者。
在调查的 31460 名受试者中，有 2871 人表现出抑郁症状，平均年龄为 48.2 岁。每周多吃一份快餐会使患抑郁症的几率增加 4%，而食用超过两份快餐会使几率增加 24%。调整后的模型探索了体重指数（BMI）、快餐消费和抑郁之间的关系，表明随着快餐摄入量的增加，风险增加，尤其是在基于肥胖状况的亚组中。中介分析表明，快餐消费和抑郁在很大程度上与肥胖无关，肥胖仅占总效应的 6.5%。在超重亚组中未发现显著的中介效应，但在更肥胖的患者中，随着 BMI 的增加，中介效应增加，尤其是在 BMI≥30 或≥40 的患者中。敏感性分析在所有亚组中使用更为保守的估计证实了这些发现。
本研究强调了快餐消费与抑郁症之间存在着实质性的联系。虽然肥胖是一个因素，但它并不能完全解释这种关系，这表明存在其他促成因素。
