Department of Fundamental Nursing, School of Nursing, Jilin University, Changchun, People's Republic of China.
Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.
J Clin Nurs. 2024 Nov;33(11):4227-4253. doi: 10.1111/jocn.17371. Epub 2024 Jul 17.
To evaluate the effectiveness and safety of nutritional interventions (i.e. nutritional support, dietary patterns and dietary supplements) on cognitive function in cancer survivors.
Systematic review.
A systematic and comprehensive search of PubMed, Web of Science, the Cochrane Library, Embase, and CINAHL was conducted from the inception until March 10, 2023. The last search was conducted on December 10, 2023.
PRISMA.
A total of 59 randomized controlled trials were included for analysis. Nutritional support, dietary patterns and dietary supplements improved cognitive function in cancer survivors with no apparent safety concerns. The anti-inflammatory diet, the fasting-mimicking diet and the web-based diet significantly improved cognitive function. Whereas the ketogenic diet or dietary advice to consume more soluble dietary fibres and less insoluble dietary fibres and lactose could not. There was evidence from dietary supplements to support the beneficial effects of polyunsaturated fatty acid supplements, traditional herbal medicines and other supplements.
Nutritional interventions have great promise for improving cognitive function in adult cancer survivors. Further validation of the nutritional interventions supported in this study in other survivors and exploration of more effective nutritional interventions are needed.
IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: This work can support the construction of nutritional support interventions and dietary guidance programs to prevent cancer-related cognitive decline.
This work filled a gap in preventive strategies for cancer-related cognitive decline from a nutritional perspective. Nutritional support, dietary patterns, and dietary supplements can prevent cancer-related cognitive decline without serious safety concerns. This work highlighted nutritional interventions that have the potential to improve cognitive function in cancer survivors, benefiting the further construction of evidence-based nutritional intervention programs.
PROSPERO.
No patient or public contribution.
评估营养干预（即营养支持、饮食模式和膳食补充剂）对癌症幸存者认知功能的有效性和安全性。
系统评价。
从创建到 2023 年 3 月 10 日，对 PubMed、Web of Science、Cochrane 图书馆、Embase 和 CINAHL 进行了系统和全面的搜索。最后一次搜索是在 2023 年 12 月 10 日进行的。
PRISMA。
共有 59 项随机对照试验被纳入分析。营养支持、饮食模式和膳食补充剂改善了癌症幸存者的认知功能，且无明显安全性问题。抗炎饮食、禁食模拟饮食和基于网络的饮食显著改善了认知功能。而生酮饮食或建议摄入更多可溶性膳食纤维、更少不可溶性膳食纤维和乳糖的饮食则不能。膳食补充剂的证据支持多不饱和脂肪酸补充剂、传统草药和其他补充剂的有益作用。
营养干预在改善成年癌症幸存者的认知功能方面具有很大的潜力。需要进一步验证本研究中支持的营养干预措施在其他幸存者中的效果，并探索更有效的营养干预措施。
专业和/或患者护理的影响：这项工作可以支持构建营养支持干预和饮食指导计划，以预防癌症相关的认知能力下降。
这项工作从营养角度填补了预防癌症相关认知能力下降策略的空白。营养支持、饮食模式和膳食补充剂可以预防癌症相关的认知能力下降，且无严重的安全问题。这项工作强调了具有改善癌症幸存者认知功能潜力的营养干预措施，有助于进一步构建基于证据的营养干预计划。
PROSPERO。
无患者或公众贡献。
