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从良性到恶性，从恶性到转移性：叶状肿瘤的生物学转变

Benign to Malignant, Malignant to Metastatic: Phyllodes Tumor Biology Transformation.

作者信息

Rai Lajpat, Gulzar Sidra, Naqi Ali, Awais Ghina, Siddiqui Sheeraz S

机构信息

Department of General Surgery, Indus Hospital & Health Network, Karachi, PAK.

Department of General Surgery, Ysbyty Gwynedd, Bangor, GBR.

出版信息

Cureus. 2024 Jun 16;16(6):e62487. doi: 10.7759/cureus.62487. eCollection 2024 Jun.

DOI:10.7759/cureus.62487
PMID:39022495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11251937/
Abstract

Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms, typically characterized by their benign nature. We present a unique case of a 29-year-old Pakistani female who initially presented with a benign PT in her left breast. Despite undergoing multiple surgical resections over the course of a decade, the tumor exhibited a remarkable transformation in biology, progressing from a benign phenotype to malignancy. Subsequent recurrences manifested with increasing aggressiveness, ultimately culminating in distant metastasis to the bones, axillary nodes, chest wall, and abdominal wall. This case underscores the unpredictable nature of PTs and highlights the challenges in managing recurrent cases with malignant transformation. The clinical course described herein emphasizes the importance of vigilant monitoring and individualized treatment strategies in such cases.

摘要

乳腺叶状肿瘤（PTs）是罕见的纤维上皮性肿瘤，通常具有良性特征。我们报告了一例独特的病例，一名29岁的巴基斯坦女性，最初其左乳出现良性PT。尽管在十年间接受了多次手术切除，但肿瘤在生物学行为上发生了显著转变，从良性表型发展为恶性。随后的复发表现出越来越强的侵袭性，最终导致远处转移至骨骼、腋窝淋巴结、胸壁和腹壁。该病例强调了PTs的不可预测性，并突出了处理发生恶性转化的复发病例时所面临的挑战。本文所述的临床过程强调了在此类病例中进行密切监测和个体化治疗策略的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/2d8451465177/cureus-0016-00000062487-i14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/e587b3c326a3/cureus-0016-00000062487-i01.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/d760a1f0da30/cureus-0016-00000062487-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/1776f52eeb96/cureus-0016-00000062487-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/f70b9ed5539c/cureus-0016-00000062487-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/cea9e66c79cf/cureus-0016-00000062487-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/79abda097afa/cureus-0016-00000062487-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/d5d66b344a30/cureus-0016-00000062487-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/8aa34be7516d/cureus-0016-00000062487-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/9b40afcfbc4c/cureus-0016-00000062487-i13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/2d8451465177/cureus-0016-00000062487-i14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/e587b3c326a3/cureus-0016-00000062487-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/3f96bb5f330f/cureus-0016-00000062487-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/f9907c6673eb/cureus-0016-00000062487-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/29ab8bb563f6/cureus-0016-00000062487-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/fcfcb6f550b6/cureus-0016-00000062487-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/d760a1f0da30/cureus-0016-00000062487-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/1776f52eeb96/cureus-0016-00000062487-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/f70b9ed5539c/cureus-0016-00000062487-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/cea9e66c79cf/cureus-0016-00000062487-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/79abda097afa/cureus-0016-00000062487-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/d5d66b344a30/cureus-0016-00000062487-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/8aa34be7516d/cureus-0016-00000062487-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/9b40afcfbc4c/cureus-0016-00000062487-i13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/11251937/2d8451465177/cureus-0016-00000062487-i14.jpg

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引用本文的文献

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本文引用的文献

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Oxf Med Case Reports. 2020 Oct 23;2020(10):omaa089. doi: 10.1093/omcr/omaa089. eCollection 2020 Oct.
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The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases.
乳腺叶状肿瘤患者的治疗与预后：170例分析
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