文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy.

作者信息

Zhang Bing-Chen, Lai Chun-Mei, Luo Bang-Yue, Shao Jing-Wei

机构信息

Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China.

Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523058, China.

出版信息

Acta Pharm Sin B. 2024 Jul;14(7):3205-3217. doi: 10.1016/j.apsb.2024.04.033. Epub 2024 May 8.

DOI:10.1016/j.apsb.2024.04.033
PMID:39027252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11252477/
Abstract

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade (ICB) monotherapy. However, combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted delivery. Herein, based on a universal triterpene template and the anticancer active agent ursolic acid (UA), a cytomembrane-coated biomimetic delivery nanoplatform (UR@M) prepared by the self-assembly of a targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma (HCC) treatment. UR@M showed enhanced tumor accumulation with homologous tumor targeting, and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% and 62.42% with no off-target effects. UA activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway, which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of . The strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor regression. Overall, the UA-templated strategy "killed three birds with one stone" by establishing a self-assembly nanosystem, inducing tumor cell death, and promoting synergistic immunostimulation for HCC treatment.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/93a2c218d380/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/bbe5f52d526e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/741a78cd3729/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/6cd304762569/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/fd43fec33b4e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/4b268b3477be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/bbef28f86ee1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/e5ecd3f26224/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/ce3968442940/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/93a2c218d380/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/bbe5f52d526e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/741a78cd3729/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/6cd304762569/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/fd43fec33b4e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/4b268b3477be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/bbef28f86ee1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/e5ecd3f26224/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/ce3968442940/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b7/11252477/93a2c218d380/gr7.jpg

相似文献

[1]
Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy.

Acta Pharm Sin B. 2024-7

[2]
Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma.

J Nanobiotechnology. 2022-7-30

[3]
Cancer-cell-biomimetic nanoparticles systemically eliminate hypoxia tumors by synergistic chemotherapy and checkpoint blockade immunotherapy.

Acta Pharm Sin B. 2022-4

[4]
Allomelanin-based biomimetic nanotherapeutics for orthotopic glioblastoma targeted photothermal immunotherapy.

Acta Biomater. 2023-8

[5]
Chemo-photodynamic therapy with light-triggered disassembly of theranostic nanoplatform in combination with checkpoint blockade for immunotherapy of hepatocellular carcinoma.

J Nanobiotechnology. 2021-10-30

[6]
A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy.

Acta Pharm Sin B. 2021-1

[7]
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way.

J Immunother Cancer. 2022-10

[8]
HSP70-Promoter-Driven CRISPR/Cas9 System Activated by Reactive Oxygen Species for Multifaceted Anticancer Immune Response and Potentiated Immunotherapy.

ACS Nano. 2022-9-27

[9]
Activation of the cGAS-STING pathway combined with CRISPR-Cas9 gene editing triggering long-term immunotherapy.

Biomaterials. 2022-12

[10]
Paclitaxel derivative-based liposomal nanoplatform for potentiated chemo-immunotherapy.

J Control Release. 2022-1

引用本文的文献

[1]
Toll-Like Receptors in the Immunotherapy Era: Dual-Edged Swords of Tumor Immunity and Clinical Translation.

MedComm (2020). 2025-7-27

[2]
The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions.

MedComm (2020). 2025-3-8

[3]
Sophisticated roles of tumor microenvironment in resistance to immune checkpoint blockade therapy in hepatocellular carcinoma.

Cancer Drug Resist. 2025-2-26

[4]
Ursolic Acid Regulates Immune Balance, Modulates Gut Microbial Metabolism, and Improves Liver Health in Mice.

Int J Mol Sci. 2024-10-2

[5]
Targeted Drug Delivery Strategies for the Treatment of Hepatocellular Carcinoma.

Molecules. 2024-9-16

本文引用的文献

[1]
Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment.

Asian J Pharm Sci. 2022-8

[2]
Lymphopenic condition enhanced the antitumor immunity of PD-1-knockout T cells mediated by CRISPR/Cas9 system in malignant melanoma.

Immunol Lett. 2022-10

[3]
HSP70-Promoter-Driven CRISPR/Cas9 System Activated by Reactive Oxygen Species for Multifaceted Anticancer Immune Response and Potentiated Immunotherapy.

ACS Nano. 2022-9-27

[4]
Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity.

ACS Nano. 2022-6-28

[5]
Genome editing of PD-L1 mediated by nucleobase-modified polyamidoamine for cancer immunotherapy.

J Mater Chem B. 2022-2-23

[6]
Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles.

Adv Drug Deliv Rev. 2021-11

[7]
Metabolizable pH/HO dual-responsive conductive polymer nanoparticles for safe and precise chemo-photothermal therapy.

Biomaterials. 2021-10

[8]
AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia.

Cancer Discov. 2021-11

[9]
Cracking the Challenge of Antimicrobial Drug Resistance with CRISPR/Cas9, Nanotechnology and Other Strategies in ESKAPE Pathogens.

Microorganisms. 2021-4-29

[10]
Novel Strategy to Combat Antibiotic Resistance: A Sight into the Combination of CRISPR/Cas9 and Nanoparticles.

Pharmaceutics. 2021-3-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索