Lafon M, Perrin P, Versmisse P, Sureau P
J Biol Stand. 1985 Oct;13(4):295-301. doi: 10.1016/s0092-1157(85)80042-1.
The use of a monoclonal antibody specific for the envelope glycoprotein of rabies virus has been used in a direct enzyme immunoassay to quantify the glycoprotein content of rabies vaccines produced in two kinds of cell culture. The results of this direct enzyme immunoassay are well correlated with the in vivo NIH potency test. This test may be a useful tool to rapidly and accurately control the antigenic value of a vaccine. It could also be used for the "in process' control of vaccine production before deciding whether a vaccine batch may reasonably be subjected to the NIH potency test.
一种针对狂犬病病毒包膜糖蛋白的单克隆抗体已被用于直接酶免疫测定，以定量两种细胞培养物中生产的狂犬病疫苗的糖蛋白含量。这种直接酶免疫测定的结果与体内NIH效力试验密切相关。该试验可能是快速准确控制疫苗抗原价值的有用工具。它还可用于疫苗生产过程中的控制，然后再决定一批疫苗是否可合理地进行NIH效力试验。
