Circuit Topology Analysis of Single-Cell HiC Data.

The 3D fold structure of the genome is intricately linked to its function. As a result, descriptors of 3D genome conformation are becoming increasingly important as markers for disease and therapeutic responses. Circuit topology, a theory of folds, formalizes the arrangement of contacts in an entangled chain. It is uniquely suited for the topological description of the cellular genome and changes to genomic architecture during physiological processes like cellular differentiation or pathological and therapeutic alterations. In this discussion, we will explore circuit topology and its ability to extract topological information from single-cell HiC data.