Kendall C H, Sanderson P R, Cope J, Talbot I C
J Clin Pathol. 1985 Oct;38(10):1100-5. doi: 10.1136/jcp.38.10.1100.
Immunocytochemical stains for laminin and type IV collagen can be used as markers for basement membrane and vascular endothelium. Thirty four follicular thyroid lesions were examined using these techniques to investigate two aspects: firstly, the relation between the extent of invasion and the integrity of basement membrane; secondly, whether the techniques could enhance the detection of tumour vascular invasion. The results showed that although basement membrane was lost in widely invasive tumours, preservation was seen in most but not all encapsulated tumours. The potential for improved recognition of vascular invasion was also found.
层粘连蛋白和IV型胶原的免疫细胞化学染色可作为基底膜和血管内皮的标志物。使用这些技术对34例甲状腺滤泡性病变进行了检查，以研究两个方面：第一，浸润程度与基底膜完整性之间的关系；第二，这些技术是否能增强对肿瘤血管浸润的检测。结果显示，虽然在广泛浸润性肿瘤中基底膜缺失，但在大多数（并非全部）包膜内肿瘤中可见基底膜保留。还发现了改善血管浸润识别的可能性。
