PMR Department, Health Science University, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
PMR Department, Marmara University School of Medicine, Istanbul, Turkey.
Musculoskelet Sci Pract. 2024 Oct;73:103147. doi: 10.1016/j.msksp.2024.103147. Epub 2024 Jul 15.
Central sensitization (CS) has an important role in chronic musculoskeletal (MSK) pain, which is one of the leading causes of disability worldwide.
To investigate the relationship between CS-related symptoms and disability in chronic MSK pain.
Multi-center cross-sectional survey.
Demographic and clinical variables including location, duration, and severity of pain were recorded. In the examination of disability, Istanbul Low Back Pain Disability Index for low back pain, Neck Pain and Disability Scale for neck pain, Quick Disability of the Arm, Shoulder, and Hand for shoulder/upper extremity pain, and Knee Injury and Osteoarthritis Outcome Score for knee pain were used. CS-related symptoms were investigated via the central sensitization inventory (CSI). Based on CSI scores, patient data were compared using the T test and an ANOVA. The association between CSI and selected variables was investigated using Pearson correlation and multivariate regression analysis.
The mean CSI score of five hundred participants was 40.46 (SD: 15.87). Patients with CSI≥40 were found to have higher levels of pain and disability and a poorer quality of life (p < 0.05). In ANOVA, significant differences between groups were observed in CS severity levels for VAS, symptom duration, and all clinical scores (p < 0.01). In the multivariate regression analysis, CSI and VAS scores were found to be related to disability in all pain groups, while pain duration was effective only in the change of knee disability.
CS-related symptoms, which are related to increased pain and disability, should be closely monitored in patients with chronic MSK pain.
中枢敏化（CS）在慢性肌肉骨骼（MSK）疼痛中起着重要作用，而慢性 MSK 疼痛是全球导致残疾的主要原因之一。
研究 CS 相关症状与慢性 MSK 疼痛患者残疾之间的关系。
多中心横断面调查。
记录人口统计学和临床变量，包括疼痛的部位、持续时间和严重程度。在评估残疾方面，使用伊斯坦布尔下腰痛残疾指数（用于腰痛）、颈痛和残疾量表（用于颈痛）、上肢肩臂手快速残疾指数（用于肩/上肢疼痛）和膝关节损伤和骨关节炎结局评分（用于膝关节疼痛）。通过中枢敏化量表（CSI）调查 CS 相关症状。根据 CSI 评分，使用 T 检验和方差分析对患者数据进行比较。使用 Pearson 相关分析和多元回归分析研究 CSI 与选定变量之间的关系。
五百名参与者的平均 CSI 得分为 40.46（标准差：15.87）。CSI≥40 的患者疼痛和残疾程度更高，生活质量更差（p<0.05）。在方差分析中，CS 严重程度的 VAS、症状持续时间和所有临床评分在组间存在显著差异（p<0.01）。在多元回归分析中，CSI 和 VAS 评分与所有疼痛组的残疾相关，而疼痛持续时间仅与膝关节残疾的变化有关。
CS 相关症状与疼痛和残疾增加有关，在慢性 MSK 疼痛患者中应密切监测。
