Department of Bone Marrow Transplantation, Beijing GoBroad Boren Hospital, Beijing, China.
Department of Medical Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.
Cancer Rep (Hoboken). 2024 Jun;7(6):e2103. doi: 10.1002/cnr2.2103.
In December 2022, a large-scale epidemic occurred in China due to Omicron variant of SARS-CoV-2. This study explored risk factors for Omicron infection in transplant recipients at our institution and investigated the factors influencing the severity of SARS-CoV-2 Omicron infection among recipients of allo-HSCT.
This single-center study investigated totally 63 allogeneic hematopoietic stem cell transplant patients infected with Omicron variant at the Beijing GoBroad Boren Hospital Transplant Center during December 2022 and analyzed their risk factors.
The study included 63 allogeneic hematopoietic stem cell transplant patients who developed Omicron infection. There were 34 mild and 29 moderate to severe cases. Their median age was 22 years (range, 1-65 years), with the male-to-female ratio being 1:1.1. Acute myeloid leukemia (53.97%), acute lymphoblastic leukemia (42.86%), and non-Hodgkin lymphoma (3.17%) were underlying diseases. The median time between HCT and Omicron infection was 8.45 months. Significant predictive factors for moderate to severe Omicron infection included older age (p < .0001), cGVHD (p = .0195), concurrent bacterial infection (p < .0001), low absolute lymphocyte count (p = .026), low CD4/CD8 ratio (p = .0091), high CRP (p < .0001), high serum ferritin (p = .0023), high D-dimer (p < .0001), low CD4 absolute count (p = .0057), and low B-cell absolute count (p = .0154). A moderate to high HCT-CI score tended to be associated with moderate to severe infection (p = .0596).
This study indicates that risk factors for severe Omicron infection include certain clinical characteristics, such as age, cGVHD, and inflammatory response.
2022 年 12 月，由于 SARS-CoV-2 的奥密克戎变异株，中国发生了大规模疫情。本研究探讨了我院移植受者感染奥密克戎的危险因素，并调查了影响异基因造血干细胞移植受者感染 SARS-CoV-2 奥密克戎严重程度的因素。
本单中心研究共调查了 2022 年 12 月北京高通博恩医院移植中心 63 例感染奥密克戎变异株的异基因造血干细胞移植患者，并分析了其危险因素。
本研究纳入了 63 例发生奥密克戎感染的异基因造血干细胞移植患者，其中轻症 34 例，中重度 29 例。中位年龄为 22 岁（范围 1-65 岁），男女比例为 1:1.1。基础疾病包括急性髓系白血病（53.97%）、急性淋巴细胞白血病（42.86%）和非霍奇金淋巴瘤（3.17%）。HCT 与奥密克戎感染之间的中位时间为 8.45 个月。中重度奥密克戎感染的显著预测因素包括年龄较大（p<0.0001）、cGVHD（p=0.0195）、合并细菌感染（p<0.0001）、绝对淋巴细胞计数较低（p=0.026）、CD4/CD8 比值较低（p=0.0091）、CRP 较高（p<0.0001）、血清铁蛋白较高（p=0.0023）、D-二聚体较高（p<0.0001）、CD4 绝对计数较低（p=0.0057）和 B 细胞绝对计数较低（p=0.0154）。较高的 HCT-CI 评分与中重度感染有一定相关性（p=0.0596）。
本研究表明，严重奥密克戎感染的危险因素包括某些临床特征，如年龄、cGVHD 和炎症反应。
