Department of Civil Engineering, Lassonde School of Engineering, York University, North York, Toronto, Ontario M3J 1P3, Canada.
Department of Civil Engineering, Lassonde School of Engineering, York University, North York, Toronto, Ontario M3J 1P3, Canada.
Microbiol Res. 2024 Oct;287:127840. doi: 10.1016/j.micres.2024.127840. Epub 2024 Jul 16.
Rhodosporidium toruloides has emerged as an excellent option for microbial lipid production due to its ability to accumulate up to 70 % of lipids per cell dry weight, consume multiple substrates such as glucose and xylose, and tolerate toxic compounds. Despite the potential of Rhodosporidium toruloides for high lipid yields, achieving these remains is a significant hurdle. A comprehensive review is essential to thoroughly evaluate the advancements in processes and technologies to enhance lipid production in R. toruloides. The review covers various strategies for enhancing lipid production like co-culture, adaptive evolution, carbon flux analysis, as well as different modes of fermentation. This review will help researchers to better understand the recent developments in technologies for sustainable and scalable lipid production from R. toruloides and simultaneously emphasize the need for developing an efficient and sustainable bioprocess.
红酵母由于其能够在细胞干重中积累高达 70%的油脂、消耗多种基质（如葡萄糖和木糖）以及耐受有毒化合物等特性，已成为微生物油脂生产的绝佳选择。尽管红酵母具有生产高油脂的潜力，但要实现这一目标仍然是一个重大的障碍。因此，对提高红酵母油脂产量的相关工艺和技术的进展进行全面的综述是至关重要的。本综述涵盖了提高油脂产量的各种策略，如共培养、适应性进化、碳通量分析以及不同的发酵方式。本综述将帮助研究人员更好地了解红酵母可持续和规模化油脂生产技术的最新发展，并同时强调需要开发高效和可持续的生物工艺。
