School of Systems Biomedical Science and Integrative Institute of Basic Sciences, Soongsil University, Seoul 06978, Republic of Korea.
School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Adv Drug Deliv Rev. 2024 Sep;212:115411. doi: 10.1016/j.addr.2024.115411. Epub 2024 Jul 19.
Pharmacological research has expanded to the nanoscale level with advanced imaging technologies, enabling the analysis of drug distribution at the cellular organelle level. These advances in research techniques have contributed to the targeting of cellular organelles to address the fundamental causes of diseases. Beyond navigating the hurdles of reaching lesion tissues upon administration and identifying target cells within these tissues, controlling drug accumulation at the organelle level is the most refined method of disease management. This approach opens new avenues for the development of more potent therapeutic strategies by delving into the intricate roles and interplay of cellular organelles. Thus, organelle-targeted approaches help overcome the limitations of conventional therapies by precisely regulating functionally compartmentalized spaces based on their environment. This review discusses the basic concepts of organelle targeting research and proposes strategies to target diseases arising from organelle dysfunction. We also address the current challenges faced by organelle targeting and explore future research directions.
随着先进成像技术的发展，药理学研究已经扩展到了纳米尺度，使我们能够在细胞细胞器水平上分析药物的分布。这些研究技术的进步有助于针对细胞细胞器进行靶向治疗，以解决疾病的根本原因。除了克服给药时到达病变组织的障碍以及在这些组织中识别靶细胞之外，在细胞器水平上控制药物积累是疾病管理的最精细方法。这种方法通过深入研究细胞器的复杂作用和相互作用，为开发更有效的治疗策略开辟了新途径。因此，细胞器靶向方法通过根据其环境精确调节功能分区空间，帮助克服传统疗法的局限性。本文讨论了细胞器靶向研究的基本概念，并提出了针对细胞器功能障碍引起的疾病的靶向策略。我们还讨论了细胞器靶向所面临的当前挑战，并探讨了未来的研究方向。
