Beasley C R, O'Donnell T V
N Z Med J. 1985 Oct 9;98(788):854-5.
The efficacy of terbutaline (1 mg) administered from pressurised aerosol through a nebuhaler was compared in a crossover trial with terbutaline (4 mg) as nebulised solution in 20 patients with acute severe asthma. The improvements following the nebuhaler, which did not require an electrical or pressure source, were worthwhile. In contrast to earlier experience in stable asthma, the increases in FEV1 (p = 0.04) and VC (p = 0.05) at 20 minutes were greater following the higher dose as nebuliser solution than following nebuhaler use. Nebuhaler technique requires individual attention since some patients with the severe asthma breathed out through the nebuhaler reservoir due to failure to close the one-way valve.
在一项交叉试验中，对20例急性重症哮喘患者使用压力气雾剂通过雾化器给予特布他林（1毫克）与使用特布他林雾化溶液（4毫克）的效果进行了比较。无需电源或压力源的雾化器带来的改善是值得的。与之前在稳定型哮喘中的经验不同，在20分钟时，作为雾化溶液使用较高剂量特布他林后的第一秒用力呼气量（FEV1，p = 0.04）和肺活量（VC，p = 0.05）的增加幅度大于使用雾化器后的增加幅度。由于一些重症哮喘患者未能关闭单向阀，通过雾化器储液器呼气，因此雾化器技术需要个别指导。
